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Dynamics and mechanism of dimer dissociation of photoreceptor UVR8

Author

Listed:
  • Xiankun Li

    (The Ohio State University
    Shanghai Jiao Tong University)

  • Zheyun Liu

    (The Ohio State University)

  • Haisheng Ren

    (University of Minnesota
    Sichuan University)

  • Mainak Kundu

    (The Ohio State University)

  • Frank W. Zhong

    (University of Chicago)

  • Lijuan Wang

    (The Ohio State University)

  • Jiali Gao

    (University of Minnesota
    Peking University Shenzhen Graduate School)

  • Dongping Zhong

    (The Ohio State University
    Shanghai Jiao Tong University)

Abstract

Photoreceptors are a class of light-sensing proteins with critical biological functions. UVR8 is the only identified UV photoreceptor in plants and its dimer dissociation upon UV sensing activates UV-protective processes. However, the dissociation mechanism is still poorly understood. Here, by integrating extensive mutations, ultrafast spectroscopy, and computational calculations, we find that the funneled excitation energy in the interfacial tryptophan (Trp) pyramid center drives a directional Trp-Trp charge separation in 80 ps and produces a critical transient Trp anion, enabling its ultrafast charge neutralization with a nearby positive arginine residue in 17 ps to destroy a key salt bridge. A domino effect is then triggered to unzip the strong interfacial interactions, which is facilitated through flooding the interface by channel and interfacial water molecules. These detailed dynamics reveal a unique molecular mechanism of UV-induced dimer monomerization.

Suggested Citation

  • Xiankun Li & Zheyun Liu & Haisheng Ren & Mainak Kundu & Frank W. Zhong & Lijuan Wang & Jiali Gao & Dongping Zhong, 2022. "Dynamics and mechanism of dimer dissociation of photoreceptor UVR8," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27756-w
    DOI: 10.1038/s41467-021-27756-w
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    1. Christopher Kupitz & Shibom Basu & Ingo Grotjohann & Raimund Fromme & Nadia A. Zatsepin & Kimberly N. Rendek & Mark S. Hunter & Robert L. Shoeman & Thomas A. White & Dingjie Wang & Daniel James & Jay-, 2014. "Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser," Nature, Nature, vol. 513(7517), pages 261-265, September.
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    Cited by:

    1. Wei Liu & Giovanni Giuriani & Anezka Havlikova & Dezhi Li & Douglas J. Lamont & Susanne Neugart & Christos N. Velanis & Jan Petersen & Ute Hoecker & John M. Christie & Gareth I. Jenkins, 2024. "Phosphorylation of Arabidopsis UVR8 photoreceptor modulates protein interactions and responses to UV-B radiation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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