IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-27375-5.html
   My bibliography  Save this article

Modulation of dopamine tone induces frequency shifts in cortico-basal ganglia beta oscillations

Author

Listed:
  • L. Iskhakova

    (The Hebrew University–Hadassah Medical School
    The Hebrew University of Jerusalem
    Weizmann Institute of Science)

  • P. Rappel

    (The Hebrew University–Hadassah Medical School
    The Hebrew University of Jerusalem)

  • M. Deffains

    (University of Bordeaux, UMR 5293, IMN
    CNRS, UMR 5293, IMN)

  • G. Fonar

    (The Hebrew University–Hadassah Medical School)

  • O. Marmor

    (The Hebrew University–Hadassah Medical School
    The Hebrew University of Jerusalem)

  • R. Paz

    (Weizmann Institute of Science)

  • Z. Israel

    (Hadassah University Hospital)

  • R. Eitan

    (The Hebrew University–Hadassah Medical School
    Hebrew University Medical School
    Brigham and Women’s Hospital, Harvard Medical School)

  • H. Bergman

    (The Hebrew University–Hadassah Medical School
    The Hebrew University of Jerusalem
    Hadassah University Hospital)

Abstract

Βeta oscillatory activity (human: 13–35 Hz; primate: 8–24 Hz) is pervasive within the cortex and basal ganglia. Studies in Parkinson’s disease patients and animal models suggest that beta-power increases with dopamine depletion. However, the exact relationship between oscillatory power, frequency and dopamine tone remains unclear. We recorded neural activity in the cortex and basal ganglia of healthy non-human primates while acutely and chronically up- and down-modulating dopamine levels. We assessed changes in beta oscillations in patients with Parkinson’s following acute and chronic changes in dopamine tone. Here we show beta oscillation frequency is strongly coupled with dopamine tone in both monkeys and humans. Power, coherence between single-units and local field potentials (LFP), spike-LFP phase-locking, and phase-amplitude coupling are not systematically regulated by dopamine levels. These results demonstrate that beta frequency is a key property of pathological oscillations in cortical and basal ganglia networks.

Suggested Citation

  • L. Iskhakova & P. Rappel & M. Deffains & G. Fonar & O. Marmor & R. Paz & Z. Israel & R. Eitan & H. Bergman, 2021. "Modulation of dopamine tone induces frequency shifts in cortico-basal ganglia beta oscillations," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27375-5
    DOI: 10.1038/s41467-021-27375-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-27375-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-27375-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Maanasa Jayachandran & Tatiana D. Viena & Andy Garcia & Abdiel Vasallo Veliz & Sofia Leyva & Valentina Roldan & Robert P. Vertes & Timothy A. Allen, 2023. "Nucleus reuniens transiently synchronizes memory networks at beta frequencies," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27375-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.