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Correlation of SARS-CoV-2-breakthrough infections to time-from-vaccine

Author

Listed:
  • Barak Mizrahi

    (KI Research Institute)

  • Roni Lotan

    (Kahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services)

  • Nir Kalkstein

    (KI Research Institute)

  • Asaf Peretz

    (Kahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services
    Internal Medicine COVID-19 Ward, Samson Assuta Ashdod University Hospital)

  • Galit Perez

    (Kahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services)

  • Amir Ben-Tov

    (Kahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services)

  • Gabriel Chodick

    (Sackler Faculty of Medicine, Tel Aviv University
    Maccabitech Institute for Research and Innovation, Maccabi Healthcare Services)

  • Sivan Gazit

    (Kahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services
    Maccabitech Institute for Research and Innovation, Maccabi Healthcare Services)

  • Tal Patalon

    (Kahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services
    Maccabitech Institute for Research and Innovation, Maccabi Healthcare Services)

Abstract

The short-term effectiveness of a two-dose regimen of the BioNTech/Pfizer mRNA BNT162b2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine was widely demonstrated. However, long term effectiveness is still unknown. Leveraging the centralized computerized database of Maccabi Healthcare Services (MHS), we assessed the correlation between time-from-vaccine and incidence of breakthrough infection between June 1 and July 27, the date of analysis. After controlling for potential confounders as age and comorbidities, we found a significant 1.51 fold (95% CI, 1.38–1.66) increased risk for infection for early vaccinees compared to those vaccinated later that was similar across all ages groups. The increased risk reached 2.26- fold (95% CI, 1.80–3.01) when comparing those who were vaccinated in January to those vaccinated in April. This preliminary finding of vaccine waning as a factor of time from vaccince should prompt further investigations into long-term protection against different strains.

Suggested Citation

  • Barak Mizrahi & Roni Lotan & Nir Kalkstein & Asaf Peretz & Galit Perez & Amir Ben-Tov & Gabriel Chodick & Sivan Gazit & Tal Patalon, 2021. "Correlation of SARS-CoV-2-breakthrough infections to time-from-vaccine," Nature Communications, Nature, vol. 12(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26672-3
    DOI: 10.1038/s41467-021-26672-3
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    Cited by:

    1. Ankita Leekha & Arash Saeedi & K M Samiur Rahman Sefat & Monish Kumar & Melisa Martinez-Paniagua & Adrian Damian & Rohan Kulkarni & Kate Reichel & Ali Rezvan & Shalaleh Masoumi & Xinli Liu & Laurence , 2024. "Multi-antigen intranasal vaccine protects against challenge with sarbecoviruses and prevents transmission in hamsters," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Christine D. Palmer & Ciaran D. Scallan & Lauren D. Kraemer Tardif & Melissa A. Kachura & Amy R. Rappaport & Daniel O. Koralek & Alison Uriel & Leonid Gitlin & Joshua Klein & Matthew J. Davis & Harshn, 2023. "GRT-R910: a self-amplifying mRNA SARS-CoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Raman, Shyam & Kriner, Douglas & Ziebarth, Nicolas & Simon, Kosali & Kreps, Sarah, 2022. "COVID-19 booster uptake among US adults: Assessing the impact of vaccine attributes, incentives, and context in a choice-based experiment," Social Science & Medicine, Elsevier, vol. 310(C).
    4. Tal Patalon & Yaki Saciuk & Asaf Peretz & Galit Perez & Yoav Lurie & Yasmin Maor & Sivan Gazit, 2022. "Waning effectiveness of the third dose of the BNT162b2 mRNA COVID-19 vaccine," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    5. Qinghong Fan & Jingrong Shi & Yanhong Yang & Guofang Tang & Mengling Jiang & Jiaojiao Li & Jingyan Tang & Lu Li & Xueliang Wen & Lieguang Zhang & Xizi Deng & Yaping Wang & Yun Lan & Liya Li & Ping Pen, 2022. "Clinical characteristics and immune profile alterations in vaccinated individuals with breakthrough Delta SARS-CoV-2 infections," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    6. Matan Levine-Tiefenbrun & Idan Yelin & Hillel Alapi & Esma Herzel & Jacob Kuint & Gabriel Chodick & Sivan Gazit & Tal Patalon & Roy Kishony, 2022. "Waning of SARS-CoV-2 booster viral-load reduction effectiveness," Nature Communications, Nature, vol. 13(1), pages 1-4, December.

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