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Spared perilesional V1 activity underlies training-induced recovery of luminance detection sensitivity in cortically-blind patients

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Listed:
  • Antoine Barbot

    (University of Rochester Medical Center
    University of Rochester
    Spinoza Centre for Neuroimaging)

  • Anasuya Das

    (University of Rochester Medical Center)

  • Michael D. Melnick

    (University of Rochester
    University of Rochester)

  • Matthew R. Cavanaugh

    (University of Rochester Medical Center
    University of Rochester)

  • Elisha P. Merriam

    (New York University
    National Institute of Mental Health, NIMH/NIH)

  • David J. Heeger

    (New York University
    New York University)

  • Krystel R. Huxlin

    (University of Rochester Medical Center
    University of Rochester
    University of Rochester)

Abstract

Damage to the primary visual cortex (V1) causes homonymous visual-field loss long considered intractable. Multiple studies now show that perceptual training can restore visual functions in chronic cortically-induced blindness (CB). A popular hypothesis is that training can harness residual visual functions by recruiting intact extrageniculostriate pathways. Training may also induce plastic changes within spared regions of the damaged V1. Here, we link changes in luminance detection sensitivity with retinotopic fMRI activity before and after visual discrimination training in eleven patients with chronic, stroke-induced CB. We show that spared V1 activity representing perimetrically-blind locations prior to training predicts the amount of training-induced recovery of luminance detection sensitivity. Additionally, training results in an enlargement of population receptive fields in perilesional V1, which increases blind-field coverage and may support further recovery with subsequent training. These findings uncover fundamental changes in perilesional V1 cortex underlying training-induced restoration of conscious luminance detection sensitivity in CB.

Suggested Citation

  • Antoine Barbot & Anasuya Das & Michael D. Melnick & Matthew R. Cavanaugh & Elisha P. Merriam & David J. Heeger & Krystel R. Huxlin, 2021. "Spared perilesional V1 activity underlies training-induced recovery of luminance detection sensitivity in cortically-blind patients," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26345-1
    DOI: 10.1038/s41467-021-26345-1
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    References listed on IDEAS

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    1. B. G. Cumming & A. J. Parker, 1997. "Responses of primary visual cortical neurons to binocular disparity without depth perception," Nature, Nature, vol. 389(6648), pages 280-283, September.
    2. Michael C. Schmid & Sylwia W. Mrowka & Janita Turchi & Richard C. Saunders & Melanie Wilke & Andrew J. Peters & Frank Q. Ye & David A. Leopold, 2010. "Blindsight depends on the lateral geniculate nucleus," Nature, Nature, vol. 466(7304), pages 373-377, July.
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