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Spontaneous traveling waves naturally emerge from horizontal fiber time delays and travel through locally asynchronous-irregular states

Author

Listed:
  • Zachary W. Davis

    (The Salk Institute for Biological Studies)

  • Gabriel B. Benigno

    (Western University
    Western University)

  • Charlee Fletterman

    (The Salk Institute for Biological Studies)

  • Theo Desbordes

    (The Salk Institute for Biological Studies)

  • Christopher Steward

    (Western University)

  • Terrence J. Sejnowski

    (The Salk Institute for Biological Studies)

  • John Reynolds

    (The Salk Institute for Biological Studies)

  • Lyle Muller

    (Western University
    Western University)

Abstract

Studies of sensory-evoked neuronal responses often focus on mean spike rates, with fluctuations treated as internally-generated noise. However, fluctuations of spontaneous activity, often organized as traveling waves, shape stimulus-evoked responses and perceptual sensitivity. The mechanisms underlying these waves are unknown. Further, it is unclear whether waves are consistent with the low rate and weakly correlated “asynchronous-irregular” dynamics observed in cortical recordings. Here, we describe a large-scale computational model with topographically-organized connectivity and conduction delays relevant to biological scales. We find that spontaneous traveling waves are a general property of these networks. The traveling waves that occur in the model are sparse, with only a small fraction of neurons participating in any individual wave. Consequently, they do not induce measurable spike correlations and remain consistent with locally asynchronous irregular states. Further, by modulating local network state, they can shape responses to incoming inputs as observed in vivo.

Suggested Citation

  • Zachary W. Davis & Gabriel B. Benigno & Charlee Fletterman & Theo Desbordes & Christopher Steward & Terrence J. Sejnowski & John Reynolds & Lyle Muller, 2021. "Spontaneous traveling waves naturally emerge from horizontal fiber time delays and travel through locally asynchronous-irregular states," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26175-1
    DOI: 10.1038/s41467-021-26175-1
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    Cited by:

    1. Dominik P. Koller & Michael Schirner & Petra Ritter, 2024. "Human connectome topology directs cortical traveling waves and shapes frequency gradients," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Gabriel B. Benigno & Roberto C. Budzinski & Zachary W. Davis & John H. Reynolds & Lyle Muller, 2023. "Waves traveling over a map of visual space can ignite short-term predictions of sensory input," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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