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A bioinspired scaffold for rapid oxygenation of cell encapsulation systems

Author

Listed:
  • Long-Hai Wang

    (Biological and Environmental Engineering, Cornell University)

  • Alexander Ulrich Ernst

    (Biological and Environmental Engineering, Cornell University)

  • Duo An

    (Biological and Environmental Engineering, Cornell University)

  • Ashim Kumar Datta

    (Biological and Environmental Engineering, Cornell University)

  • Boris Epel

    (The University of Chicago)

  • Mrignayani Kotecha

    (O2M Technologies, LLC)

  • Minglin Ma

    (Biological and Environmental Engineering, Cornell University)

Abstract

Inadequate oxygenation is a major challenge in cell encapsulation, a therapy which holds potential to treat many diseases including type I diabetes. In such systems, cellular oxygen (O2) delivery is limited to slow passive diffusion from transplantation sites through the poorly O2-soluble encapsulating matrix, usually a hydrogel. This constrains the maximum permitted distance between the encapsulated cells and host site to within a few hundred micrometers to ensure cellular function. Inspired by the natural gas-phase tracheal O2 delivery system of insects, we present herein the design of a biomimetic scaffold featuring internal continuous air channels endowed with 10,000-fold higher O2 diffusivity than hydrogels. We incorporate the scaffold into a bulk hydrogel containing cells, which facilitates rapid O2 transport through the whole system to cells several millimeters away from the device-host boundary. A computational model, validated by in vitro analysis, predicts that cells and islets maintain high viability even in a thick (6.6 mm) device. Finally, the therapeutic potential of the device is demonstrated through the correction of diabetes in immunocompetent mice using rat islets for over 6 months.

Suggested Citation

  • Long-Hai Wang & Alexander Ulrich Ernst & Duo An & Ashim Kumar Datta & Boris Epel & Mrignayani Kotecha & Minglin Ma, 2021. "A bioinspired scaffold for rapid oxygenation of cell encapsulation systems," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26126-w
    DOI: 10.1038/s41467-021-26126-w
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    References listed on IDEAS

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    1. Iain D. Couzin & Jens Krause & Nigel R. Franks & Simon A. Levin, 2005. "Effective leadership and decision-making in animal groups on the move," Nature, Nature, vol. 433(7025), pages 513-516, February.
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    Cited by:

    1. Hamoon Hemmatpour & Oreste Luca & Dominic Crestani & Marc C. A. Stuart & Alessia Lasorsa & Patrick C. A. Wel & Katja Loos & Theodosis Giousis & Vahid Haddadi-Asl & Petra Rudolf, 2023. "New insights in polydopamine formation via surface adsorption," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Jesus Paez-Mayorga & Jocelyn Nikita Campa-Carranza & Simone Capuani & Nathanael Hernandez & Hsuan-Chen Liu & Corrine Ying Xuan Chua & Fernanda Paola Pons-Faudoa & Gulsah Malgir & Bella Alvarez & Jean , 2022. "Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Alexander U. Ernst & Long-Hai Wang & Scott C. Worland & Braulio A. Marfil-Garza & Xi Wang & Wanjun Liu & Alan Chiu & Tatsuya Kin & Doug O’Gorman & Scott Steinschneider & Ashim K. Datta & Klearchos K. , 2022. "A predictive computational platform for optimizing the design of bioartificial pancreas devices," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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