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Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer

Author

Listed:
  • Kerui Wu

    (Wake Forest University School of Medicine)

  • Jiamei Feng

    (Wake Forest University School of Medicine
    Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine)

  • Feng Lyu

    (Wake Forest University School of Medicine
    Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University)

  • Fei Xing

    (Wake Forest University School of Medicine)

  • Sambad Sharma

    (Wake Forest University School of Medicine)

  • Yin Liu

    (Wake Forest University School of Medicine)

  • Shih-Ying Wu

    (Wake Forest University School of Medicine)

  • Dan Zhao

    (Wake Forest University School of Medicine)

  • Abhishek Tyagi

    (Wake Forest University School of Medicine)

  • Ravindra Pramod Deshpande

    (Wake Forest University School of Medicine)

  • Xinhong Pei

    (Wake Forest University School of Medicine
    The First Affiliated Hospital of Zhengzhou University)

  • Marco Gabril Ruiz

    (Wake Forest University School of Medicine)

  • Hiroyuki Takahashi

    (Jikei University School of Medicine)

  • Shunsuke Tsuzuki

    (Jikei University School of Medicine)

  • Takahiro Kimura

    (Jikei University School of Medicine)

  • Yin-yuan Mo

    (University of Mississippi Medical Center)

  • Yusuke Shiozawa

    (Wake Forest University School of Medicine)

  • Ravi Singh

    (Wake Forest University School of Medicine)

  • Kounosuke Watabe

    (Wake Forest University School of Medicine)

Abstract

Bone metastasis is an incurable complication of breast cancer. In advanced stages, patients with estrogen-positive tumors experience a significantly higher incidence of bone metastasis (>87%) compared to estrogen-negative patients (

Suggested Citation

  • Kerui Wu & Jiamei Feng & Feng Lyu & Fei Xing & Sambad Sharma & Yin Liu & Shih-Ying Wu & Dan Zhao & Abhishek Tyagi & Ravindra Pramod Deshpande & Xinhong Pei & Marco Gabril Ruiz & Hiroyuki Takahashi & S, 2021. "Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25473-y
    DOI: 10.1038/s41467-021-25473-y
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    Cited by:

    1. Liang, Weijuan & Zhang, Qingzhao & Ma, Shuangge, 2024. "Hierarchical false discovery rate control for high-dimensional survival analysis with interactions," Computational Statistics & Data Analysis, Elsevier, vol. 192(C).
    2. Dan Zhao & Kerui Wu & Sambad Sharma & Fei Xing & Shih-Ying Wu & Abhishek Tyagi & Ravindra Deshpande & Ravi Singh & Martin Wabitsch & Yin-Yuan Mo & Kounosuke Watabe, 2022. "Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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