Author
Listed:
- Danielle J. Ingle
(Australian National University
The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)
- Rebecca L. Ambrose
(Hudson Institute of Medical Research
Monash University
Monash University)
- Sarah L. Baines
(The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)
- Sebastian Duchene
(The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)
- Anders Gonçalves da Silva
(The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)
- Darren Y. J. Lee
(The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)
- Miriam Jones
(Hudson Institute of Medical Research
Monash University
Monash University)
- Mary Valcanis
(The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)
- George Taiaroa
(The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)
- Susan A. Ballard
(The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)
- Martyn D. Kirk
(Australian National University)
- Benjamin P. Howden
(The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)
- Jaclyn S. Pearson
(Hudson Institute of Medical Research
Monash University
Monash University)
- Deborah A. Williamson
(The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Royal Melbourne Hospital)
Abstract
Salmonella enterica serovar 4,[5],12:i:- (Salmonella 4,[5],12:i:-) is a monophasic variant of Salmonella Typhimurium that has emerged as a global cause of multidrug resistant salmonellosis. We used Bayesian phylodynamics, genomic epidemiology, and phenotypic characterization to describe the emergence and evolution of Salmonella 4,[5],12:i:- in Australia. We show that the interruption of the genetic region surrounding the phase II flagellin, FljB, causing a monophasic phenotype, represents a stepwise evolutionary event through the accumulation of mobile resistance elements with minimal impairment to bacterial fitness. We identify three lineages with different population dynamics and discrete antimicrobial resistance profiles emerged, likely reflecting differential antimicrobial selection pressures. Two lineages are associated with travel to South-East Asia and the third lineage is endemic to Australia. Moreover antimicrobial-resistant Salmonella 4,[5],12:i- lineages efficiently infected and survived in host phagocytes and epithelial cells without eliciting significant cellular cytotoxicity, suggesting a suppression of host immune response that may facilitate the persistence of Salmonella 4,[5],12:i:-.
Suggested Citation
Danielle J. Ingle & Rebecca L. Ambrose & Sarah L. Baines & Sebastian Duchene & Anders Gonçalves da Silva & Darren Y. J. Lee & Miriam Jones & Mary Valcanis & George Taiaroa & Susan A. Ballard & Martyn , 2021.
"Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4,[5],12:i:- in Australia,"
Nature Communications, Nature, vol. 12(1), pages 1-13, December.
Handle:
RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25073-w
DOI: 10.1038/s41467-021-25073-w
Download full text from publisher
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25073-w. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.