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Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4,[5],12:i:- in Australia

Author

Listed:
  • Danielle J. Ingle

    (Australian National University
    The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
    The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Rebecca L. Ambrose

    (Hudson Institute of Medical Research
    Monash University
    Monash University)

  • Sarah L. Baines

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Sebastian Duchene

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Anders Gonçalves da Silva

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Darren Y. J. Lee

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Miriam Jones

    (Hudson Institute of Medical Research
    Monash University
    Monash University)

  • Mary Valcanis

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • George Taiaroa

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Susan A. Ballard

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Martyn D. Kirk

    (Australian National University)

  • Benjamin P. Howden

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
    The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Jaclyn S. Pearson

    (Hudson Institute of Medical Research
    Monash University
    Monash University)

  • Deborah A. Williamson

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
    The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
    Royal Melbourne Hospital)

Abstract

Salmonella enterica serovar 4,[5],12:i:- (Salmonella 4,[5],12:i:-) is a monophasic variant of Salmonella Typhimurium that has emerged as a global cause of multidrug resistant salmonellosis. We used Bayesian phylodynamics, genomic epidemiology, and phenotypic characterization to describe the emergence and evolution of Salmonella 4,[5],12:i:- in Australia. We show that the interruption of the genetic region surrounding the phase II flagellin, FljB, causing a monophasic phenotype, represents a stepwise evolutionary event through the accumulation of mobile resistance elements with minimal impairment to bacterial fitness. We identify three lineages with different population dynamics and discrete antimicrobial resistance profiles emerged, likely reflecting differential antimicrobial selection pressures. Two lineages are associated with travel to South-East Asia and the third lineage is endemic to Australia. Moreover antimicrobial-resistant Salmonella 4,[5],12:i- lineages efficiently infected and survived in host phagocytes and epithelial cells without eliciting significant cellular cytotoxicity, suggesting a suppression of host immune response that may facilitate the persistence of Salmonella 4,[5],12:i:-.

Suggested Citation

  • Danielle J. Ingle & Rebecca L. Ambrose & Sarah L. Baines & Sebastian Duchene & Anders Gonçalves da Silva & Darren Y. J. Lee & Miriam Jones & Mary Valcanis & George Taiaroa & Susan A. Ballard & Martyn , 2021. "Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4,[5],12:i:- in Australia," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25073-w
    DOI: 10.1038/s41467-021-25073-w
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    Cited by:

    1. Ying Xiang & Kunpeng Zhu & Kaiyuan Min & Yaowen Zhang & Jiangfeng Liu & Kangkang Liu & Yiran Han & Xinge Li & Xinying Du & Xin Wang & Ying Huang & Xinping Li & Yuqian Peng & Chaojie Yang & Hongbo Liu , 2024. "Characterization of a Salmonella enterica serovar Typhimurium lineage with rough colony morphology and multidrug resistance," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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