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Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field

Author

Listed:
  • Andrew Hammond

    (Imperial College London
    Johns Hopkins University)

  • Paola Pollegioni

    (Polo d’Innovazione di Genomica Genetica e Biologia
    National Research Council Research Institute on Terrestrial Ecosystems)

  • Tania Persampieri

    (Polo d’Innovazione di Genomica Genetica e Biologia)

  • Ace North

    (University of Oxford)

  • Roxana Minuz

    (Polo d’Innovazione di Genomica Genetica e Biologia)

  • Alessandro Trusso

    (Polo d’Innovazione di Genomica Genetica e Biologia)

  • Alessandro Bucci

    (Polo d’Innovazione di Genomica Genetica e Biologia)

  • Kyros Kyrou

    (Imperial College London)

  • Ioanna Morianou

    (Imperial College London)

  • Alekos Simoni

    (Imperial College London
    Polo d’Innovazione di Genomica Genetica e Biologia)

  • Tony Nolan

    (Imperial College London
    Liverpool School of Tropical Medicine)

  • Ruth Müller

    (Polo d’Innovazione di Genomica Genetica e Biologia
    Goethe University
    Institute of Tropical Medicine Antwerp)

  • Andrea Crisanti

    (Imperial College London)

Abstract

CRISPR-based gene-drives targeting the gene doublesex in the malaria vector Anopheles gambiae effectively suppressed the reproductive capability of mosquito populations reared in small laboratory cages. To bridge the gap between laboratory and the field, this gene-drive technology must be challenged with vector ecology. Here we report the suppressive activity of the gene-drive in age-structured An. gambiae populations in large indoor cages that permit complex feeding and reproductive behaviours. The gene-drive element spreads rapidly through the populations, fully supresses the population within one year and without selecting for resistance to the gene drive. Approximate Bayesian computation allowed retrospective inference of life-history parameters from the large cages and a more accurate prediction of gene-drive behaviour under more ecologically-relevant settings. Generating data to bridge laboratory and field studies for invasive technologies is challenging. Our study represents a paradigm for the stepwise and sound development of vector control tools based on gene-drive.

Suggested Citation

  • Andrew Hammond & Paola Pollegioni & Tania Persampieri & Ace North & Roxana Minuz & Alessandro Trusso & Alessandro Bucci & Kyros Kyrou & Ioanna Morianou & Alekos Simoni & Tony Nolan & Ruth Müller & And, 2021. "Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24790-6
    DOI: 10.1038/s41467-021-24790-6
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    Cited by:

    1. Alena L. Bishop & Víctor López Del Amo & Emily M. Okamoto & Zsolt Bodai & Alexis C. Komor & Valentino M. Gantz, 2022. "Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Penelope A. Hancock & Ace North & Adrian W. Leach & Peter Winskill & Azra C. Ghani & H. Charles J. Godfray & Austin Burt & John D. Mumford, 2024. "The potential of gene drives in malaria vector species to control malaria in African environments," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Jones, Michael S. & Brown, Zachary S., 2023. "Food for thought: Assessing the consumer welfare impacts of deploying irreversible, landscape-scale biotechnologies," Food Policy, Elsevier, vol. 121(C).

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