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Structure of the molecular bushing of the bacterial flagellar motor

Author

Listed:
  • Tomoko Yamaguchi

    (Osaka University
    RIKEN Center for Biosystems Dynamics Research)

  • Fumiaki Makino

    (Osaka University
    JEOL Ltd.)

  • Tomoko Miyata

    (Osaka University)

  • Tohru Minamino

    (Osaka University)

  • Takayuki Kato

    (Osaka University
    Osaka University)

  • Keiichi Namba

    (Osaka University
    RIKEN Center for Biosystems Dynamics Research
    RIKEN SPring-8 Center
    Osaka University)

Abstract

The basal body of the bacterial flagellum is a rotary motor that consists of several rings (C, MS and LP) and a rod. The LP ring acts as a bushing supporting the distal rod for its rapid and stable rotation without much friction. Here, we use electron cryomicroscopy to describe the LP ring structure around the rod, at 3.5 Å resolution, from Salmonella Typhimurium. The structure shows 26-fold rotational symmetry and intricate intersubunit interactions of each subunit with up to six partners, which explains the structural stability. The inner surface is charged both positively and negatively. Positive charges on the P ring (the part of the LP ring that is embedded within the peptidoglycan layer) presumably play important roles in its initial assembly around the rod with a negatively charged surface.

Suggested Citation

  • Tomoko Yamaguchi & Fumiaki Makino & Tomoko Miyata & Tohru Minamino & Takayuki Kato & Keiichi Namba, 2021. "Structure of the molecular bushing of the bacterial flagellar motor," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24715-3
    DOI: 10.1038/s41467-021-24715-3
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    Cited by:

    1. Haidai Hu & Philipp F. Popp & Mònica Santiveri & Aritz Roa-Eguiara & Yumeng Yan & Freddie J. O. Martin & Zheyi Liu & Navish Wadhwa & Yong Wang & Marc Erhardt & Nicholas M. I. Taylor, 2023. "Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Rebecca Conners & Mathew McLaren & Urszula Łapińska & Kelly Sanders & M. Rhia L. Stone & Mark A. T. Blaskovich & Stefano Pagliara & Bertram Daum & Jasna Rakonjac & Vicki A. M. Gold, 2021. "CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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