IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-24654-z.html
   My bibliography  Save this article

Combating mosquito-borne diseases using genetic control technologies

Author

Listed:
  • Guan-Hong Wang

    (University of California
    Chinese Academy of Sciences)

  • Stephanie Gamez

    (University of California)

  • Robyn R. Raban

    (University of California)

  • John M. Marshall

    (University of California
    Innovative Genomics Institute)

  • Luke Alphey

    (The Pirbright Institute)

  • Ming Li

    (University of California)

  • Jason L. Rasgon

    (The Pennsylvania State University
    The Pennsylvania State University
    The Pennsylvania State University)

  • Omar S. Akbari

    (University of California)

Abstract

Mosquito-borne diseases, such as dengue and malaria, pose significant global health burdens. Unfortunately, current control methods based on insecticides and environmental maintenance have fallen short of eliminating the disease burden. Scalable, deployable, genetic-based solutions are sought to reduce the transmission risk of these diseases. Pathogen-blocking Wolbachia bacteria, or genome engineering-based mosquito control strategies including gene drives have been developed to address these problems, both requiring the release of modified mosquitoes into the environment. Here, we review the latest developments, notable similarities, and critical distinctions between these promising technologies and discuss their future applications for mosquito-borne disease control.

Suggested Citation

  • Guan-Hong Wang & Stephanie Gamez & Robyn R. Raban & John M. Marshall & Luke Alphey & Ming Li & Jason L. Rasgon & Omar S. Akbari, 2021. "Combating mosquito-borne diseases using genetic control technologies," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24654-z
    DOI: 10.1038/s41467-021-24654-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-24654-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-24654-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Stephanie Gamez & Duverney Chaverra-Rodriguez & Anna Buchman & Nikolay P. Kandul & Stelia C. Mendez-Sanchez & Jared B. Bennett & Héctor M. Sánchez C. & Ting Yang & Igor Antoshechkin & Jonny E. Duque &, 2021. "Exploiting a Y chromosome-linked Cas9 for sex selection and gene drive," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24654-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.