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Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia

Author

Listed:
  • Urs Braun

    (University of Heidelberg
    University of Pennsylvania)

  • Anais Harneit

    (University of Heidelberg)

  • Giulio Pergola

    (University of Bari Aldo Moro)

  • Tommaso Menara

    (University of California at Riverside)

  • Axel Schäfer

    (Justus Liebig University Giessen
    University of Marburg and Justus Liebig University Giessen)

  • Richard F. Betzel

    (Indiana University)

  • Zhenxiang Zang

    (University of Heidelberg)

  • Janina I. Schweiger

    (University of Heidelberg)

  • Xiaolong Zhang

    (University of Heidelberg)

  • Kristina Schwarz

    (University of Heidelberg)

  • Junfang Chen

    (University of Heidelberg)

  • Giuseppe Blasi

    (University of Bari Aldo Moro)

  • Alessandro Bertolino

    (University of Bari Aldo Moro)

  • Daniel Durstewitz

    (University of Heidelberg)

  • Fabio Pasqualetti

    (University of California at Riverside)

  • Emanuel Schwarz

    (University of Heidelberg)

  • Andreas Meyer-Lindenberg

    (University of Heidelberg)

  • Danielle S. Bassett

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

  • Heike Tost

    (University of Heidelberg)

Abstract

Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory performance entails brain-wide switching between activity states using a combination of functional magnetic resonance imaging in healthy controls and individuals with schizophrenia, pharmacological fMRI, genetic analyses and network control theory. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression and pharmacological modulation. Individuals with schizophrenia show altered network control properties, including a more diverse energy landscape and decreased stability of working memory representations. Our results demonstrate the relevance of dopamine signaling for the steering of whole-brain network dynamics during working memory and link these processes to schizophrenia pathophysiology.

Suggested Citation

  • Urs Braun & Anais Harneit & Giulio Pergola & Tommaso Menara & Axel Schäfer & Richard F. Betzel & Zhenxiang Zang & Janina I. Schweiger & Xiaolong Zhang & Kristina Schwarz & Junfang Chen & Giuseppe Blas, 2021. "Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23694-9
    DOI: 10.1038/s41467-021-23694-9
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    Cited by:

    1. Leonardo Sportelli & Daniel P. Eisenberg & Roberta Passiatore & Enrico D’Ambrosio & Linda A. Antonucci & Jasmine S. Bettina & Qiang Chen & Aaron L. Goldman & Michael D. Gregory & Kira Griffiths & Thom, 2024. "Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Huili Sun & Rongtao Jiang & Wei Dai & Alexander J. Dufford & Stephanie Noble & Marisa N. Spann & Shi Gu & Dustin Scheinost, 2023. "Network controllability of structural connectomes in the neonatal brain," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. S. Parker Singleton & Andrea I. Luppi & Robin L. Carhart-Harris & Josephine Cruzat & Leor Roseman & David J. Nutt & Gustavo Deco & Morten L. Kringelbach & Emmanuel A. Stamatakis & Amy Kuceyeski, 2022. "Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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