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Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences

Author

Listed:
  • K. Shaw

    (University of Sussex, Falmer)

  • L. Bell

    (University of Sussex, Falmer)

  • K. Boyd

    (University of Sussex, Falmer)

  • D. M. Grijseels

    (University of Sussex, Falmer)

  • D. Clarke

    (University of Sussex, Falmer)

  • O. Bonnar

    (University of Sussex, Falmer)

  • H. S. Crombag

    (University of Sussex, Falmer)

  • C. N. Hall

    (University of Sussex, Falmer)

Abstract

The hippocampus is essential for spatial and episodic memory but is damaged early in Alzheimer’s disease and is very sensitive to hypoxia. Understanding how it regulates its oxygen supply is therefore key for designing interventions to preserve its function. However, studies of neurovascular function in the hippocampus in vivo have been limited by its relative inaccessibility. Here we compared hippocampal and visual cortical neurovascular function in awake mice, using two photon imaging of individual neurons and vessels and measures of regional blood flow and haemoglobin oxygenation. We show that blood flow, blood oxygenation and neurovascular coupling were decreased in the hippocampus compared to neocortex, because of differences in both the vascular network and pericyte and endothelial cell function. Modelling oxygen diffusion indicates that these features of the hippocampal vasculature may restrict oxygen availability and could explain its sensitivity to damage during neurological conditions, including Alzheimer’s disease, where the brain’s energy supply is decreased.

Suggested Citation

  • K. Shaw & L. Bell & K. Boyd & D. M. Grijseels & D. Clarke & O. Bonnar & H. S. Crombag & C. N. Hall, 2021. "Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23508-y
    DOI: 10.1038/s41467-021-23508-y
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    Cited by:

    1. Alejandro Moreno-Domínguez & Olalla Colinas & Ignacio Arias-Mayenco & José M. Cabeza & Juan L. López-Ogayar & Navdeep S. Chandel & Norbert Weissmann & Natascha Sommer & Alberto Pascual & José López-Ba, 2024. "Hif1α-dependent mitochondrial acute O2 sensing and signaling to myocyte Ca2+ channels mediate arterial hypoxic vasodilation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Xin Rui Lim & Mohammad M. Abd-Alhaseeb & Michael Ippolito & Masayo Koide & Amanda J. Senatore & Curtis Plante & Ashwini Hariharan & Nick Weir & Thomas A. Longden & Kathryn A. Laprade & James M. Staffo, 2024. "Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Andrée-Anne Berthiaume & Franca Schmid & Stefan Stamenkovic & Vanessa Coelho-Santos & Cara D. Nielson & Bruno Weber & Mark W. Majesky & Andy Y. Shih, 2022. "Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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