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Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform

Author

Listed:
  • Wei A. Huang

    (University of North Carolina
    University of North Carolina
    University of North Carolina)

  • Iain M. Stitt

    (University of North Carolina
    University of North Carolina)

  • Ehsan Negahbani

    (University of North Carolina
    University of North Carolina)

  • D. J. Passey

    (University of North Carolina
    University of North Carolina)

  • Sangtae Ahn

    (University of North Carolina
    University of North Carolina
    Kyungpook National University)

  • Marshall Davey

    (University of North Carolina
    University of North Carolina)

  • Moritz Dannhauer

    (Duke University)

  • Thien T. Doan

    (Duke University
    Duke University)

  • Anna C. Hoover

    (Duke University)

  • Angel V. Peterchev

    (Duke University
    Duke University
    Duke University
    Duke University)

  • Susanne Radtke-Schuller

    (University of North Carolina
    University of North Carolina)

  • Flavio Fröhlich

    (University of North Carolina
    University of North Carolina
    University of North Carolina
    University of North Carolina)

Abstract

Computational modeling and human studies suggest that transcranial alternating current stimulation (tACS) modulates alpha oscillations by entrainment. Yet, a direct examination of how tACS interacts with neuronal spiking activity that gives rise to the alpha oscillation in the thalamo-cortical system has been lacking. Here, we demonstrate how tACS entrains endogenous alpha oscillations in head-fixed awake ferrets. We first show that endogenous alpha oscillations in the posterior parietal cortex drive the primary visual cortex and the higher-order visual thalamus. Spike-field coherence is largest for the alpha frequency band, and presumed fast-spiking inhibitory interneurons exhibit strongest coupling to this oscillation. We then apply alpha-tACS that results in a field strength comparable to what is commonly used in humans (

Suggested Citation

  • Wei A. Huang & Iain M. Stitt & Ehsan Negahbani & D. J. Passey & Sangtae Ahn & Marshall Davey & Moritz Dannhauer & Thien T. Doan & Anna C. Hoover & Angel V. Peterchev & Susanne Radtke-Schuller & Flavio, 2021. "Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform," Nature Communications, Nature, vol. 12(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23021-2
    DOI: 10.1038/s41467-021-23021-2
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    Cited by:

    1. Miles Wischnewski & Harry Tran & Zhihe Zhao & Sina Shirinpour & Zachary J. Haigh & Jonna Rotteveel & Nipun D. Perera & Ivan Alekseichuk & Jan Zimmermann & Alexander Opitz, 2024. "Induced neural phase precession through exogenous electric fields," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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