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The impact of stopping and starting indoor residual spraying on malaria burden in Uganda

Author

Listed:
  • Jane F. Namuganga

    (Infectious Diseases Research Collaboration)

  • Adrienne Epstein

    (University of California San Francisco)

  • Joaniter I. Nankabirwa

    (Infectious Diseases Research Collaboration
    Makerere University, College of Health Sciences)

  • Arthur Mpimbaza

    (Infectious Diseases Research Collaboration
    Makerere University, College of Health Sciences)

  • Moses Kiggundu

    (Infectious Diseases Research Collaboration)

  • Asadu Sserwanga

    (Infectious Diseases Research Collaboration)

  • James Kapisi

    (Infectious Diseases Research Collaboration)

  • Emmanuel Arinaitwe

    (Infectious Diseases Research Collaboration)

  • Samuel Gonahasa

    (Infectious Diseases Research Collaboration)

  • Jimmy Opigo

    (Ministry of Health)

  • Chris Ebong

    (Infectious Diseases Research Collaboration)

  • Sarah G. Staedke

    (London School of Hygiene and Tropical Medicine)

  • Josephat Shililu

    (US President’s Malaria Initiative – VectorLink Uganda Project)

  • Michael Okia

    (US President’s Malaria Initiative – VectorLink Uganda Project)

  • Damian Rutazaana

    (Ministry of Health)

  • Catherine Maiteki-Sebuguzi

    (Ministry of Health)

  • Kassahun Belay

    (US President’s Malaria Initiative, USAID/Uganda Senior Malaria Advisor)

  • Moses R. Kamya

    (Infectious Diseases Research Collaboration
    Makerere University, College of Health Sciences)

  • Grant Dorsey

    (University of California San Francisco)

  • Isabel Rodriguez-Barraquer

    (University of California San Francisco)

Abstract

The scale-up of malaria control efforts has led to marked reductions in malaria burden over the past twenty years, but progress has slowed. Implementation of indoor residual spraying (IRS) of insecticide, a proven vector control intervention, has been limited and difficult to sustain partly because questions remain on its added impact over widely accepted interventions such as bed nets. Using data from 14 enhanced surveillance health facilities in Uganda, a country with high bed net coverage yet high malaria burden, we estimate the impact of starting and stopping IRS on changes in malaria incidence. We show that stopping IRS was associated with a 5-fold increase in malaria incidence within 10 months, but reinstating IRS was associated with an over 5-fold decrease within 8 months. In areas where IRS was initiated and sustained, malaria incidence dropped by 85% after year 4. IRS could play a critical role in achieving global malaria targets, particularly in areas where progress has stalled.

Suggested Citation

  • Jane F. Namuganga & Adrienne Epstein & Joaniter I. Nankabirwa & Arthur Mpimbaza & Moses Kiggundu & Asadu Sserwanga & James Kapisi & Emmanuel Arinaitwe & Samuel Gonahasa & Jimmy Opigo & Chris Ebong & S, 2021. "The impact of stopping and starting indoor residual spraying on malaria burden in Uganda," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22896-5
    DOI: 10.1038/s41467-021-22896-5
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    Cited by:

    1. Margaux L. Sadoine & Audrey Smargiassi & Ying Liu & Philippe Gachon & Michel Fournier & Guillaume Dueymes & Jane Frances Namuganga & Grant Dorsey & Bouchra Nasri & Kate Zinszer, 2023. "Differential Influence of Environmental Factors on Malaria Due to Vector Control Interventions in Uganda," IJERPH, MDPI, vol. 20(22), pages 1-13, November.
    2. Ellie Sherrard-Smith & Corine Ngufor & Antoine Sanou & Moussa W. Guelbeogo & Raphael N’Guessan & Eldo Elobolobo & Francisco Saute & Kenyssony Varela & Carlos J. Chaccour & Rose Zulliger & Joseph Wagma, 2022. "Inferring the epidemiological benefit of indoor vector control interventions against malaria from mosquito data," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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