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Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer

Author

Listed:
  • Zhiyong Wang

    (University of California San Diego)

  • Yusuke Goto

    (University of California San Diego)

  • Michael M. Allevato

    (University of California San Diego
    University of California San Diego)

  • Victoria H. Wu

    (University of California San Diego
    University of California San Diego)

  • Robert Saddawi-Konefka

    (University of California San Diego
    Division of Otolaryngology-Head and Neck Surgery, UC San Diego School of Medicine)

  • Mara Gilardi

    (University of California San Diego)

  • Diego Alvarado

    (Celldex Therapeutics)

  • Bryan S. Yung

    (University of California San Diego
    University of California San Diego)

  • Aoife O’Farrell

    (University of California San Diego)

  • Alfredo A. Molinolo

    (University of California San Diego)

  • Umamaheswar Duvvuri

    (University of Pittsburgh School of Medicine)

  • Jennifer R. Grandis

    (University of California San Francisco)

  • Joseph A. Califano

    (University of California San Diego
    Division of Otolaryngology-Head and Neck Surgery, UC San Diego School of Medicine)

  • Ezra E. W. Cohen

    (University of California San Diego)

  • J. Silvio Gutkind

    (University of California San Diego
    University of California San Diego)

Abstract

Immune checkpoint blockade (ICB) therapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, but

Suggested Citation

  • Zhiyong Wang & Yusuke Goto & Michael M. Allevato & Victoria H. Wu & Robert Saddawi-Konefka & Mara Gilardi & Diego Alvarado & Bryan S. Yung & Aoife O’Farrell & Alfredo A. Molinolo & Umamaheswar Duvvuri, 2021. "Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22619-w
    DOI: 10.1038/s41467-021-22619-w
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    Cited by:

    1. Robert Saddawi-Konefka & Aoife O’Farrell & Farhoud Faraji & Lauren Clubb & Michael M. Allevato & Shawn M. Jensen & Bryan S. Yung & Zhiyong Wang & Victoria H. Wu & Nana-Ama Anang & Riyam Al Msari & Shi, 2022. "Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Dina V. Hingorani & Michael M. Allevato & Maria F. Camargo & Jacqueline Lesperance & Maryam A. Quraishi & Joseph Aguilera & Ida Franiak-Pietryga & Daniel J. Scanderbeg & Zhiyong Wang & Alfredo A. Moli, 2022. "Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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