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Enzymatic enhancing of triplet–triplet annihilation upconversion by breaking oxygen quenching for background-free biological sensing

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  • Ling Huang

    (University of Massachusetts Medical School)

  • Timmy Le

    (University of Massachusetts Medical School)

  • Kai Huang

    (University of Massachusetts Medical School)

  • Gang Han

    (University of Massachusetts Medical School)

Abstract

Triplet-triplet annihilation upconversion nanoparticles have attracted considerable interest due to their promises in organic chemistry, solar energy harvesting and several biological applications. However, triplet-triplet annihilation upconversion in aqueous solutions is challenging due to sensitivity to oxygen, hindering its biological applications under ambient atmosphere. Herein, we report a simple enzymatic strategy to overcome oxygen-induced triplet-triplet annihilation upconversion quenching. This strategy stems from a glucose oxidase catalyzed glucose oxidation reaction, which enables rapid oxygen depletion to turn on upconversion in the aqueous solution. Furthermore, self-standing upconversion biological sensors of such nanoparticles are developed to detect glucose and measure the activity of enzymes related to glucose metabolism in a highly specific, sensitive and background-free manner. This study not only overcomes the key roadblock for applications of triplet-triplet annihilation upconversion nanoparticles in aqueous solutions, it also establishes the proof-of-concept to develop triplet-triplet annihilation upconversion nanoparticles as background free self-standing biological sensors.

Suggested Citation

  • Ling Huang & Timmy Le & Kai Huang & Gang Han, 2021. "Enzymatic enhancing of triplet–triplet annihilation upconversion by breaking oxygen quenching for background-free biological sensing," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22282-1
    DOI: 10.1038/s41467-021-22282-1
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    Cited by:

    1. Xinyu Wang & Fangwei Ding & Tao Jia & Feng Li & Xiping Ding & Ruibin Deng & Kaifeng Lin & Yulin Yang & Wenzhi Wu & Debin Xia & Guanying Chen, 2024. "Molecular near-infrared triplet-triplet annihilation upconversion with eigen oxygen immunity," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Pengqing Bi & Tao Zhang & Yuanyuan Guo & Jianqiu Wang & Xian Wei Chua & Zhihao Chen & Wei Peng Goh & Changyun Jiang & Elbert E. M. Chia & Jianhui Hou & Le Yang, 2024. "Donor-acceptor bulk-heterojunction sensitizer for efficient solid-state infrared-to-visible photon up-conversion," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Tonghan Zhao & Dejing Meng & Zhijian Hu & Wenjing Sun & Yinglu Ji & Jianlei Han & Xue Jin & Xiaochun Wu & Pengfei Duan, 2023. "Enhanced chiroptic properties of nanocomposites of achiral plasmonic nanoparticles decorated with chiral dye-loaded micelles," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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