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Photonic resonator interferometric scattering microscopy

Author

Listed:
  • Nantao Li

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Taylor D. Canady

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Qinglan Huang

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Xing Wang

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Glenn A. Fried

    (University of Illinois at Urbana-Champaign)

  • Brian T. Cunningham

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign
    Cancer Center at Illinois)

Abstract

Interferometric scattering microscopy is increasingly employed in biomedical research owing to its extraordinary capability of detecting nano-objects individually through their intrinsic elastic scattering. To significantly improve the signal-to-noise ratio without increasing illumination intensity, we developed photonic resonator interferometric scattering microscopy (PRISM) in which a dielectric photonic crystal (PC) resonator is utilized as the sample substrate. The scattered light is amplified by the PC through resonant near-field enhancement, which then interferes with the

Suggested Citation

  • Nantao Li & Taylor D. Canady & Qinglan Huang & Xing Wang & Glenn A. Fried & Brian T. Cunningham, 2021. "Photonic resonator interferometric scattering microscopy," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21999-3
    DOI: 10.1038/s41467-021-21999-3
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    Cited by:

    1. Guangjie Cui & Yunbo Liu & Di Zu & Xintao Zhao & Zhijia Zhang & Do Young Kim & Pramith Senaratne & Aaron Fox & David Sept & Younggeun Park & Somin Eunice Lee, 2023. "Phase intensity nanoscope (PINE) opens long-time investigation windows of living matter," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Amani A. Hariri & Sharon S. Newman & Steven Tan & Dan Mamerow & Alexandra M. Adams & Nicolò Maganzini & Brian L. Zhong & Michael Eisenstein & Alexander R. Dunn & H. Tom Soh, 2022. "Improved immunoassay sensitivity and specificity using single-molecule colocalization," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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