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Applications, challenges, and needs for employing synthetic biology beyond the lab

Author

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  • Sierra M. Brooks

    (The University of Texas at Austin)

  • Hal S. Alper

    (The University of Texas at Austin
    The University of Texas at Austin)

Abstract

Synthetic biology holds great promise for addressing global needs. However, most current developments are not immediately translatable to ‘outside-the-lab’ scenarios that differ from controlled laboratory settings. Challenges include enabling long-term storage stability as well as operating in resource-limited and off-the-grid scenarios using autonomous function. Here we analyze recent advances in developing synthetic biological platforms for outside-the-lab scenarios with a focus on three major application spaces: bioproduction, biosensing, and closed-loop therapeutic and probiotic delivery. Across the Perspective, we highlight recent advances, areas for further development, possibilities for future applications, and the needs for innovation at the interface of other disciplines.

Suggested Citation

  • Sierra M. Brooks & Hal S. Alper, 2021. "Applications, challenges, and needs for employing synthetic biology beyond the lab," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21740-0
    DOI: 10.1038/s41467-021-21740-0
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    Cited by:

    1. Debika Datta & Elliot L. Weiss & Daniel Wangpraseurt & Erica Hild & Shaochen Chen & James W. Golden & Susan S. Golden & Jonathan K. Pokorski, 2023. "Phenotypically complex living materials containing engineered cyanobacteria," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Sierra M. Brooks & Celeste Marsan & Kevin B. Reed & Shuo-Fu Yuan & Dustin-Dat Nguyen & Adit Trivedi & Gokce Altin-Yavuzarslan & Nathan Ballinger & Alshakim Nelson & Hal S. Alper, 2023. "A tripartite microbial co-culture system for de novo biosynthesis of diverse plant phenylpropanoids," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Li Tang & Jennifer Kuzma & Xi Zhang & Xinyu Song & Yin Li & Hongxu Liu & Guangyuan Hu, 2023. "Synthetic biology and governance research in China: a 40-year evolution," Scientometrics, Springer;Akadémiai Kiadó, vol. 128(9), pages 5293-5310, September.

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