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Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children

Author

Listed:
  • Melanie R. Neeland

    (Murdoch Children’s Research Institute
    The University of Melbourne)

  • Samantha Bannister

    (Murdoch Children’s Research Institute
    The University of Melbourne
    The Royal Children’s Hospital)

  • Vanessa Clifford

    (Murdoch Children’s Research Institute
    The University of Melbourne
    The Royal Children’s Hospital)

  • Kate Dohle

    (The University of Melbourne)

  • Kim Mulholland

    (Murdoch Children’s Research Institute
    The University of Melbourne)

  • Philip Sutton

    (Murdoch Children’s Research Institute
    The University of Melbourne)

  • Nigel Curtis

    (Murdoch Children’s Research Institute
    The University of Melbourne
    The Royal Children’s Hospital)

  • Andrew C. Steer

    (Murdoch Children’s Research Institute
    The University of Melbourne
    The Royal Children’s Hospital)

  • David P. Burgner

    (Murdoch Children’s Research Institute
    The University of Melbourne
    The Royal Children’s Hospital)

  • Nigel W. Crawford

    (Murdoch Children’s Research Institute
    The University of Melbourne
    The Royal Children’s Hospital)

  • Shidan Tosif

    (Murdoch Children’s Research Institute
    The University of Melbourne
    The Royal Children’s Hospital)

  • Richard Saffery

    (Murdoch Children’s Research Institute
    The University of Melbourne)

Abstract

Children have mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confirmed disease (COVID-19) compared to adults and the immunological mechanisms underlying this difference remain unclear. Here, we report acute and convalescent innate immune responses in 48 children and 70 adults infected with, or exposed to, SARS-CoV-2. We find clinically mild SARS-CoV-2 infection in children is characterised by reduced circulating subsets of monocytes (classical, intermediate, non-classical), dendritic cells and natural killer cells during the acute phase. In contrast, SARS-CoV-2-infected adults show reduced proportions of non-classical monocytes only. We also observe increased proportions of CD63+ activated neutrophils during the acute phase to SARS-CoV-2 in infected children. Children and adults exposed to SARS-CoV-2 but negative on PCR testing display increased proportions of low-density neutrophils that we observe up to 7 weeks post exposure. This study characterises the innate immune response during SARS-CoV-2 infection and household exposure in children.

Suggested Citation

  • Melanie R. Neeland & Samantha Bannister & Vanessa Clifford & Kate Dohle & Kim Mulholland & Philip Sutton & Nigel Curtis & Andrew C. Steer & David P. Burgner & Nigel W. Crawford & Shidan Tosif & Richar, 2021. "Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children," Nature Communications, Nature, vol. 12(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21414-x
    DOI: 10.1038/s41467-021-21414-x
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    Cited by:

    1. Alessia Raineri & Thomas Radtke & Sonja Rueegg & Sarah R. Haile & Dominik Menges & Tala Ballouz & Agne Ulyte & Jan Fehr & Daniel L. Cornejo & Giuseppe Pantaleo & Céline Pellaton & Craig Fenwick & Milo, 2023. "Persistent humoral immune response in youth throughout the COVID-19 pandemic: prospective school-based cohort study," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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