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Facilitation of molecular motion to develop turn-on photoacoustic bioprobe for detecting nitric oxide in encephalitis

Author

Listed:
  • Ji Qi

    (The Hong Kong University of Science and Technology)

  • Leyan Feng

    (Nankai University, Haihe Education Park)

  • Xiaoyan Zhang

    (Nankai University)

  • Haoke Zhang

    (The Hong Kong University of Science and Technology)

  • Liwen Huang

    (Nankai University, Haihe Education Park)

  • Yutong Zhou

    (Nankai University, Haihe Education Park)

  • Zheng Zhao

    (The Hong Kong University of Science and Technology)

  • Xingchen Duan

    (Nankai University)

  • Fei Xu

    (Nankai University, Haihe Education Park)

  • Ryan T. K. Kwok

    (The Hong Kong University of Science and Technology
    HKUST-Shenzhen Research Institute)

  • Jacky W. Y. Lam

    (The Hong Kong University of Science and Technology
    HKUST-Shenzhen Research Institute)

  • Dan Ding

    (Nankai University)

  • Xue Xue

    (Nankai University, Haihe Education Park)

  • Ben Zhong Tang

    (The Hong Kong University of Science and Technology
    HKUST-Shenzhen Research Institute
    South China University of Technology)

Abstract

Nitric oxide (NO) is an important signaling molecule overexpressed in many diseases, thus the development of NO-activatable probes is of vital significance for monitoring related diseases. However, sensitive photoacoustic (PA) probes for detecting NO-associated complicated diseases (e.g., encephalitis), have yet to be developed. Herein, we report a NO-activated PA probe for in vivo detection of encephalitis by tuning the molecular geometry and energy transformation processes. A strong donor-acceptor structure with increased conjugation can be obtained after NO treatment, along with the active intramolecular motion, significantly boosting “turn-on” near-infrared PA property. The molecular probe exhibits high specificity and sensitivity towards NO over interfering reactive species. The probe is capable of detecting and differentiating encephalitis in different severities with high spatiotemporal resolution. This work will inspire more insights into the development of high-performing activatable PA probes for advanced diagnosis by making full use of intramolecular motion and energy transformation processes.

Suggested Citation

  • Ji Qi & Leyan Feng & Xiaoyan Zhang & Haoke Zhang & Liwen Huang & Yutong Zhou & Zheng Zhao & Xingchen Duan & Fei Xu & Ryan T. K. Kwok & Jacky W. Y. Lam & Dan Ding & Xue Xue & Ben Zhong Tang, 2021. "Facilitation of molecular motion to develop turn-on photoacoustic bioprobe for detecting nitric oxide in encephalitis," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21208-1
    DOI: 10.1038/s41467-021-21208-1
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    Cited by:

    1. Xiaoying Kang & Yuan Zhang & Jianwen Song & Lu Wang & Wen Li & Ji Qi & Ben Zhong Tang, 2023. "A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Jianwen Song & Xiaoying Kang & Lu Wang & Dan Ding & Deling Kong & Wen Li & Ji Qi, 2023. "Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Lin-Lin Yang & Haoran Wang & Jianyu Zhang & Bo Wu & Qiyao Li & Jie-Ying Chen & A-Ling Tang & Jacky W. Y. Lam & Zheng Zhao & Song Yang & Ben Zhong Tang, 2024. "Understanding the AIE phenomenon of nonconjugated rhodamine derivatives via aggregation-induced molecular conformation change," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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