IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-21155-x.html
   My bibliography  Save this article

Lasting antibody and T cell responses to SARS-CoV-2 in COVID-19 patients three months after infection

Author

Listed:
  • Xiao-Lin Jiang

    (Shandong Provincial Center for Disease Control and Prevention)

  • Guo-Lin Wang

    (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology)

  • Xiang-Na Zhao

    (Chinese People’s Liberation Army)

  • Fei-Hu Yan

    (Academy of Military Medical Sciences)

  • Lin Yao

    (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology)

  • Zeng-Qiang Kou

    (Shandong Provincial Center for Disease Control and Prevention)

  • Sheng-Xiang Ji

    (Linyi Center for Disease Control and Prevention)

  • Xiao-Li Zhang

    (Linyi Center for Disease Control and Prevention)

  • Cun-Bao Li

    (Linyi Center for Disease Control and Prevention)

  • Li-Jun Duan

    (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology)

  • Yan Li

    (Shandong Provincial Center for Disease Control and Prevention)

  • Yu-Wen Zhang

    (Shandong Provincial Center for Disease Control and Prevention)

  • Qing Duan

    (Shandong Provincial Center for Disease Control and Prevention)

  • Tie-Cheng Wang

    (Academy of Military Medical Sciences)

  • En-Tao Li

    (Academy of Military Medical Sciences)

  • Xiao Wei

    (Chinese People’s Liberation Army)

  • Qing-Yang Wang

    (Beijing Institute of Brain Science)

  • Xue-Feng Wang

    (Academy of Military Medical Sciences)

  • Wei-Yang Sun

    (Academy of Military Medical Sciences)

  • Yu-Wei Gao

    (Academy of Military Medical Sciences)

  • Dian-Min Kang

    (Shandong Provincial Center for Disease Control and Prevention)

  • Ji-Yan Zhang

    (Beijing Institute of Brain Science)

  • Mai-Juan Ma

    (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology)

Abstract

The dynamics, duration, and nature of immunity produced during SARS-CoV-2 infection are still unclear. Here, we longitudinally measured virus-neutralising antibody, specific antibodies against the spike (S) protein, receptor-binding domain (RBD), and the nucleoprotein (N) of SARS-CoV-2, as well as T cell responses, in 25 SARS-CoV-2-infected patients up to 121 days post-symptom onset (PSO). All patients seroconvert for IgG against N, S, or RBD, as well as IgM against RBD, and produce neutralising antibodies (NAb) by 14 days PSO, with the peak levels attained by 15–30 days PSO. Anti-SARS-CoV-2 IgG and NAb remain detectable and relatively stable 3–4 months PSO, whereas IgM antibody rapidly decay. Approximately 65% of patients have detectable SARS-CoV-2-specific CD4+ or CD8+ T cell responses 3–4 months PSO. Our results thus provide critical evidence that IgG, NAb, and T cell responses persist in the majority of patients for at least 3–4 months after infection.

Suggested Citation

  • Xiao-Lin Jiang & Guo-Lin Wang & Xiang-Na Zhao & Fei-Hu Yan & Lin Yao & Zeng-Qiang Kou & Sheng-Xiang Ji & Xiao-Li Zhang & Cun-Bao Li & Li-Jun Duan & Yan Li & Yu-Wen Zhang & Qing Duan & Tie-Cheng Wang &, 2021. "Lasting antibody and T cell responses to SARS-CoV-2 in COVID-19 patients three months after infection," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21155-x
    DOI: 10.1038/s41467-021-21155-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-21155-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-21155-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ankita Leekha & Arash Saeedi & K M Samiur Rahman Sefat & Monish Kumar & Melisa Martinez-Paniagua & Adrian Damian & Rohan Kulkarni & Kate Reichel & Ali Rezvan & Shalaleh Masoumi & Xinli Liu & Laurence , 2024. "Multi-antigen intranasal vaccine protects against challenge with sarbecoviruses and prevents transmission in hamsters," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Irene A. Abela & Chloé Pasin & Magdalena Schwarzmüller & Selina Epp & Michèle E. Sickmann & Merle M. Schanz & Peter Rusert & Jacqueline Weber & Stefan Schmutz & Annette Audigé & Liridona Maliqi & Anni, 2021. "Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity," Nature Communications, Nature, vol. 12(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21155-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.