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NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines

Author

Listed:
  • Yuli He

    (Nanjing University)

  • Huayue Song

    (Nanjing University)

  • Jian Chen

    (Nanjing University)

  • Shaolin Zhu

    (Nanjing University)

Abstract

Enantiomerically pure chiral amines and related amide derivatives are privilege motifs in many pharmacologically active molecules. In comparison to the well-established hydroamination, the transition metal-catalysed asymmetric hydrofunctionalization of enamines provides a complementary approach for their construction. Here we report a NiH-catalysed enantio- and regioselective reductive hydroarylation of N-acyl enamines, allowing for the practical access to a broad range of structurally diverse, enantioenriched benzylamines under mild, operationally simple reaction conditions.

Suggested Citation

  • Yuli He & Huayue Song & Jian Chen & Shaolin Zhu, 2021. "NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20888-5
    DOI: 10.1038/s41467-020-20888-5
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    Cited by:

    1. Qian Gao & Wei-Cheng Xu & Xuan Nie & Kang-Jie Bian & Hong-Rui Yuan & Wen Zhang & Bing-Bing Wu & Xi-Sheng Wang, 2024. "Regio‐ and enantioselective nickel-alkyl catalyzed hydroalkylation of alkynes," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Dong Liu & Zhao-Ran Liu & Zhen-Hua Wang & Cong Ma & Simon Herbert & Hartmut Schirok & Tian-Sheng Mei, 2022. "Paired electrolysis-enabled nickel-catalyzed enantioselective reductive cross-coupling between α-chloroesters and aryl bromides," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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