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Perspectives on skeletal muscle stem cells

Author

Listed:
  • F. Relaix

    (Univ Paris Est Creteil, INSERM, IMRB
    EnvA, IMRB
    EFS, IMRB
    AP-HP, Hopital Mondor, Service d’histologie)

  • M. Bencze

    (Univ Paris Est Creteil, INSERM, IMRB)

  • M. J. Borok

    (Univ Paris Est Creteil, INSERM, IMRB)

  • A. Vartanian

    (Univ Paris Est Creteil, INSERM, IMRB)

  • F. Gattazzo

    (Univ Paris Est Creteil, INSERM, IMRB
    EFS, IMRB)

  • D. Mademtzoglou

    (Univ Paris Est Creteil, INSERM, IMRB)

  • S. Perez-Diaz

    (Univ Paris Est Creteil, INSERM, IMRB)

  • A. Prola

    (Univ Paris Est Creteil, INSERM, IMRB
    EnvA, IMRB)

  • P. C. Reyes-Fernandez

    (Univ Paris Est Creteil, INSERM, IMRB)

  • A. Rotini

    (Univ Paris Est Creteil, INSERM, IMRB)

  • Taglietti

    (Univ Paris Est Creteil, INSERM, IMRB)

Abstract

Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle stem cells (MuSCs). In this review, we introduce recently developed technologies and the mechanistic insights they provide to the understanding of MuSC biology, including the re-definition of quiescence and Galert states. Additionally, we present recent studies that link MuSC function with cellular heterogeneity, highlighting the complex regulation of self-renewal in regeneration, muscle disorders and aging. Finally, we discuss MuSC metabolism and its role, as well as the multifaceted regulation of MuSCs by their niche. The presented conceptual advances in the MuSC field impact on our general understanding of stem cells and their therapeutic use in regenerative medicine.

Suggested Citation

  • F. Relaix & M. Bencze & M. J. Borok & A. Vartanian & F. Gattazzo & D. Mademtzoglou & S. Perez-Diaz & A. Prola & P. C. Reyes-Fernandez & A. Rotini & Taglietti, 2021. "Perspectives on skeletal muscle stem cells," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20760-6
    DOI: 10.1038/s41467-020-20760-6
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    Cited by:

    1. Ting Zhang & Carsten Künne & Dong Ding & Stefan Günther & Xinyue Guo & Yonggang Zhou & Xuejun Yuan & Thomas Braun, 2022. "Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Jiayin Peng & Lili Han & Biao Liu & Jiawen Song & Yuang Wang & Kunpeng Wang & Qian Guo & XinYan Liu & Yu Li & Jujin Zhang & Wenqing Wu & Sheng Li & Xin Fu & Cheng-le Zhuang & Weikang Zhang & Shengbao , 2023. "Gli1 marks a sentinel muscle stem cell population for muscle regeneration," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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