IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-020-20760-6.html
   My bibliography  Save this article

Perspectives on skeletal muscle stem cells

Author

Listed:
  • F. Relaix

    (Univ Paris Est Creteil, INSERM, IMRB
    EnvA, IMRB
    EFS, IMRB
    AP-HP, Hopital Mondor, Service d’histologie)

  • M. Bencze

    (Univ Paris Est Creteil, INSERM, IMRB)

  • M. J. Borok

    (Univ Paris Est Creteil, INSERM, IMRB)

  • A. Vartanian

    (Univ Paris Est Creteil, INSERM, IMRB)

  • F. Gattazzo

    (Univ Paris Est Creteil, INSERM, IMRB
    EFS, IMRB)

  • D. Mademtzoglou

    (Univ Paris Est Creteil, INSERM, IMRB)

  • S. Perez-Diaz

    (Univ Paris Est Creteil, INSERM, IMRB)

  • A. Prola

    (Univ Paris Est Creteil, INSERM, IMRB
    EnvA, IMRB)

  • P. C. Reyes-Fernandez

    (Univ Paris Est Creteil, INSERM, IMRB)

  • A. Rotini

    (Univ Paris Est Creteil, INSERM, IMRB)

  • Taglietti

    (Univ Paris Est Creteil, INSERM, IMRB)

Abstract

Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle stem cells (MuSCs). In this review, we introduce recently developed technologies and the mechanistic insights they provide to the understanding of MuSC biology, including the re-definition of quiescence and Galert states. Additionally, we present recent studies that link MuSC function with cellular heterogeneity, highlighting the complex regulation of self-renewal in regeneration, muscle disorders and aging. Finally, we discuss MuSC metabolism and its role, as well as the multifaceted regulation of MuSCs by their niche. The presented conceptual advances in the MuSC field impact on our general understanding of stem cells and their therapeutic use in regenerative medicine.

Suggested Citation

  • F. Relaix & M. Bencze & M. J. Borok & A. Vartanian & F. Gattazzo & D. Mademtzoglou & S. Perez-Diaz & A. Prola & P. C. Reyes-Fernandez & A. Rotini & Taglietti, 2021. "Perspectives on skeletal muscle stem cells," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20760-6
    DOI: 10.1038/s41467-020-20760-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-20760-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-20760-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ting Zhang & Carsten Künne & Dong Ding & Stefan Günther & Xinyue Guo & Yonggang Zhou & Xuejun Yuan & Thomas Braun, 2022. "Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Jiayin Peng & Lili Han & Biao Liu & Jiawen Song & Yuang Wang & Kunpeng Wang & Qian Guo & XinYan Liu & Yu Li & Jujin Zhang & Wenqing Wu & Sheng Li & Xin Fu & Cheng-le Zhuang & Weikang Zhang & Shengbao , 2023. "Gli1 marks a sentinel muscle stem cell population for muscle regeneration," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Chengyi Sun & Casey O. Swoboda & Fabian Montecino Morales & Cristofer Calvo & Michael J. Petrany & Sreeja Parameswaran & Andrew VonHandorf & Matthew T. Weirauch & Christoph Lepper & Douglas P. Millay, 2024. "Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20760-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.