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circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

Author

Listed:
  • Botai Li

    (Shanghai Jiao Tong University School of Biomedical Engineering)

  • Lili Zhu

    (Shanghai Jiao Tong University School of Biomedical Engineering)

  • Chunlai Lu

    (Fudan University)

  • Cun Wang

    (Shanghai Jiao Tong University School of Medicine)

  • Hui Wang

    (Shanghai Jiao Tong University School of Medicine)

  • Haojie Jin

    (Shanghai Jiao Tong University School of Medicine)

  • Xuhui Ma

    (Shanghai Jiao Tong University School of Medicine)

  • Zhuoan Cheng

    (Shanghai Jiao Tong University School of Biomedical Engineering)

  • Chengtao Yu

    (Shanghai Jiao Tong University School of Biomedical Engineering)

  • Siying Wang

    (Shanghai Jiao Tong University School of Medicine)

  • Qiaozhu Zuo

    (Shanghai Jiao Tong University School of Medicine)

  • Yangyang Zhou

    (Shanghai Jiao Tong University School of Medicine)

  • Jun Wang

    (Shanghai Jiao Tong University School of Medicine)

  • Chen Yang

    (Shanghai Jiao Tong University School of Medicine)

  • Yuanyuan Lv

    (Shanghai Jiao Tong University School of Medicine)

  • Liyan Jiang

    (Shanghai Jiao Tong University)

  • Wenxin Qin

    (Shanghai Jiao Tong University School of Biomedical Engineering
    Shanghai Jiao Tong University School of Medicine)

Abstract

Circular RNAs (circRNA) are a class of covalently closed single-stranded RNAs that have been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated in non-small cell lung cancer (NSCLC) tissues, and to negatively correlate with NSCLC malignant features. Elevated circNDUFB2 inhibits growth and metastasis of NSCLC cells. Mechanistically, circNDUFB2 functions as a scaffold to enhance the interaction between TRIM25 and IGF2BPs, a positive regulator of tumor progression and metastasis. This TRIM25/circNDUFB2/IGF2BPs ternary complex facilitates ubiquitination and degradation of IGF2BPs, with this effect enhanced by N6-methyladenosine (m6A) modification of circNDUFB2. Moreover, circNDUFB2 is also recognized by RIG-I to activate RIG-I-MAVS signaling cascades and recruit immune cells into the tumor microenvironment (TME). Our data thus provide evidences that circNDUFB2 participates in the degradation of IGF2BPs and activation of anti-tumor immunity during NSCLC progression via the modulation of both protein ubiquitination and degradation, as well as cellular immune responses.

Suggested Citation

  • Botai Li & Lili Zhu & Chunlai Lu & Cun Wang & Hui Wang & Haojie Jin & Xuhui Ma & Zhuoan Cheng & Chengtao Yu & Siying Wang & Qiaozhu Zuo & Yangyang Zhou & Jun Wang & Chen Yang & Yuanyuan Lv & Liyan Jia, 2021. "circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20527-z
    DOI: 10.1038/s41467-020-20527-z
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    Cited by:

    1. Qilin Huang & Ziqiang Chu & Zihao Wang & Qiankun Li & Sheng Meng & Yao Lu & Kui Ma & Shengnan Cui & Wenzhi Hu & Wenhua Zhang & Qian Wei & Yanlin Qu & Haihong Li & Xiaobing Fu & Cuiping Zhang, 2024. "circCDK13-loaded small extracellular vesicles accelerate healing in preclinical diabetic wound models," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Zhe Gong & Jinjin Zhu & Junxin Chen & Fan Feng & Haitao Zhang & Zheyuan Zhang & Chenxin Song & Kaiyu Liang & Shuhui Yang & Shunwu Fan & Xiangqian Fang & Shuying Shen, 2023. "CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    3. Zehua Shang & Sitao Zhang & Jinrui Wang & Lili Zhou & Xinyue Zhang & Daniel D. Billadeau & Peiguo Yang & Lingqiang Zhang & Fangfang Zhou & Peng Bai & Da Jia, 2024. "TRIM25 predominately associates with anti-viral stress granules," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Chi Zhou & Wenxin Li & Zhenxing Liang & Xianrui Wu & Sijing Cheng & Jianhong Peng & Kaixuan Zeng & Weihao Li & Ping Lan & Xin Yang & Li Xiong & Ziwei Zeng & Xiaobin Zheng & Liang Huang & Wenhua Fan & , 2024. "Mutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    5. Bin Li & Wen Xi & Ying Bai & Xue Liu & Yuan Zhang & Lu Li & Liang Bian & Chenchen Liu & Ying Tang & Ling Shen & Li Yang & Xiaochun Gu & Jian Xie & Zhongqiu Zhou & Yu Wang & Xiaoyu Yu & Jianhong Wang &, 2023. "FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    6. Wenjuan Zhang & Bowei Zhou & Xiao Yang & Jin Zhao & Jingjuan Hu & Yuqi Ding & Shuteng Zhan & Yifeng Yang & Jun Chen & Fu Zhang & Bingcheng Zhao & Fan Deng & Zebin Lin & Qishun Sun & Fangling Zhang & Z, 2023. "Exosomal circEZH2_005, an intestinal injury biomarker, alleviates intestinal ischemia/reperfusion injury by mediating Gprc5a signaling," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    7. Peng Wang & Zhitao Huang & Yili Peng & Hongwei Li & Tong Lin & Yingyu Zhao & Zheng Hu & Zhanmei Zhou & Weijie Zhou & Youhua Liu & Fan Fan Hou, 2022. "Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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