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Mechanisms of muscle atrophy and hypertrophy: implications in health and disease

Author

Listed:
  • Roberta Sartori

    (University of Padova
    Veneto Institute of Molecular Medicine)

  • Vanina Romanello

    (University of Padova
    Veneto Institute of Molecular Medicine)

  • Marco Sandri

    (University of Padova
    Veneto Institute of Molecular Medicine
    University of Padova
    McGill University)

Abstract

Skeletal muscle is the protein reservoir of our body and an important regulator of glucose and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence general metabolism, locomotion, eating and respiration. Therefore, it is not surprising that excessive muscle loss is a bad prognostic index of a variety of diseases ranging from cancer, organ failure, infections and unhealthy ageing. Muscle function is influenced by different quality systems that regulate the function of contractile proteins and organelles. These systems are controlled by transcriptional dependent programs that adapt muscle cells to environmental and nutritional clues. Mechanical, oxidative, nutritional and energy stresses, as well as growth factors or cytokines modulate signaling pathways that, ultimately, converge on protein and organelle turnover. Novel insights that control and orchestrate such complex network are continuously emerging and will be summarized in this review. Understanding the mechanisms that control muscle mass will provide therapeutic targets for the treatment of muscle loss in inherited and non-hereditary diseases and for the improvement of the quality of life during ageing.

Suggested Citation

  • Roberta Sartori & Vanina Romanello & Marco Sandri, 2021. "Mechanisms of muscle atrophy and hypertrophy: implications in health and disease," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20123-1
    DOI: 10.1038/s41467-020-20123-1
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    Cited by:

    1. Jean-Philippe Leduc-Gaudet & Anais Franco-Romero & Marina Cefis & Alaa Moamer & Felipe E. Broering & Giulia Milan & Roberta Sartori & Tomer Jordi Chaffer & Maude Dulac & Vincent Marcangeli & Dominique, 2023. "MYTHO is a novel regulator of skeletal muscle autophagy and integrity," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Anirban Roy & Ashok Kumar, 2022. "Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Hongchun Lin & Hui Peng & Yuxiang Sun & Meijun Si & Jiao Wu & Yanlin Wang & Sandhya S. Thomas & Zheng Sun & Zhaoyong Hu, 2023. "Reprogramming of cis-regulatory networks during skeletal muscle atrophy in male mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Flavia A. Graca & Anna Stephan & Benjamin A. Minden-Birkenmaier & Abbas Shirinifard & Yong-Dong Wang & Fabio Demontis & Myriam Labelle, 2023. "Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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