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Neonicotinoid Clothianidin reduces honey bee immune response and contributes to Varroa mite proliferation

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  • Desiderato Annoscia

    (Dipartimento di Scienze AgroAlimentari, Ambientali e Animali, Università degli Studi di Udine)

  • Gennaro Di Prisco

    (Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”
    CREA, Consiglio per la Ricerca in Agricoltura e l’Analisi dell’Economia Agraria, Centro di Ricerca Agricoltura e Ambiente)

  • Andrea Becchimanzi

    (Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”)

  • Emilio Caprio

    (Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”)

  • Davide Frizzera

    (Dipartimento di Scienze AgroAlimentari, Ambientali e Animali, Università degli Studi di Udine)

  • Alberto Linguadoca

    (Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”
    Department of Biological Sciences, Royal Holloway, University of London)

  • Francesco Nazzi

    (Dipartimento di Scienze AgroAlimentari, Ambientali e Animali, Università degli Studi di Udine)

  • Francesco Pennacchio

    (Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”)

Abstract

The neonicotinoid Clothianidin has a negative impact on NF-κB signaling and on immune responses controlled by this transcription factor, which can boost the proliferation of honey bee parasites and pathogens. This effect has been well documented for the replication of deformed wing virus (DWV) induced by Clothianidin in honey bees bearing an asymptomatic infection. Here, we conduct infestation experiments of treated bees to show that the immune-suppression exerted by Clothianidin is associated with an enhanced fertility of the parasitic mite Varroa destructor, as a possible consequence of a higher feeding efficiency. A conceptual model is proposed to describe the synergistic interactions among different stress agents acting on honey bees.

Suggested Citation

  • Desiderato Annoscia & Gennaro Di Prisco & Andrea Becchimanzi & Emilio Caprio & Davide Frizzera & Alberto Linguadoca & Francesco Nazzi & Francesco Pennacchio, 2020. "Neonicotinoid Clothianidin reduces honey bee immune response and contributes to Varroa mite proliferation," Nature Communications, Nature, vol. 11(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19715-8
    DOI: 10.1038/s41467-020-19715-8
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    Cited by:

    1. Dong Sheng & Siyuan Jing & Xueqing He & Alexandra-Maria Klein & Heinz-R. Köhler & Thomas C. Wanger, 2024. "Plastic pollution in agricultural landscapes: an overlooked threat to pollination, biocontrol and food security," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Agnieszka Murawska & Paweł Migdał & Adam Roman, 2021. "Effects of Plant Protection Products on Biochemical Markers in Honey Bees," Agriculture, MDPI, vol. 11(7), pages 1-14, July.
    3. Dimitri Breda & Davide Frizzera & Giulia Giordano & Elisa Seffin & Virginia Zanni & Desiderato Annoscia & Christopher J. Topping & Franco Blanchini & Francesco Nazzi, 2022. "A deeper understanding of system interactions can explain contradictory field results on pesticide impact on honey bees," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Yinying Yang & Yuzheng Wu & Hexuan Long & Xuelin Ma & Kaavian Shariati & James Webb & Liang Guo & Yang Pan & Minglin Ma & Chao Deng & Peng Cao & Jing Chen, 2023. "Global honeybee health decline factors and potential conservation techniques," Food Security: The Science, Sociology and Economics of Food Production and Access to Food, Springer;The International Society for Plant Pathology, vol. 15(4), pages 855-875, August.

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