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Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics

Author

Listed:
  • Yang Zhang

    (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University)

  • Xiaoyong Wang

    (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
    State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University)

  • Chengchao Chu

    (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University)

  • Zijian Zhou

    (Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore)

  • Biaoqi Chen

    (Fujian Provincial Key Laboratory of Biochemical Technology, Institute of Biomaterials and Tissue Engineering, Huaqiao University)

  • Xin Pang

    (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University)

  • Gan Lin

    (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University)

  • Huirong Lin

    (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University)

  • Yuxin Guo

    (Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University)

  • En Ren

    (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University)

  • Peng Lv

    (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University)

  • Yesi Shi

    (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University)

  • Qingbing Zheng

    (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
    State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University)

  • Xiaohui Yan

    (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University)

  • Xiaoyuan Chen

    (Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore)

  • Gang Liu

    (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
    State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University)

Abstract

The clinical applications of magnetic hyperthermia therapy (MHT) have been largely hindered by the poor magnetic-to-thermal conversion efficiency of MHT agents. Herein, we develop a facile and efficient strategy for engineering encapsulin-produced magnetic iron oxide nanocomposites (eMIONs) via a green biomineralization procedure. We demonstrate that eMIONs have excellent magnetic saturation and remnant magnetization properties, featuring superior magnetic-to-thermal conversion efficiency with an ultrahigh specific absorption rate of 2390 W/g to overcome the critical issues of MHT. We also show that eMIONs act as a nanozyme and have enhanced catalase-like activity in the presence of an alternative magnetic field, leading to tumor angiogenesis inhibition with a corresponding sharp decrease in the expression of HIF-1α. The inherent excellent magnetic-heat capability, coupled with catalysis-triggered tumor suppression, allows eMIONs to provide an MRI-guided magneto-catalytic combination therapy, which may open up a new avenue for bench-to-bed translational research of MHT.

Suggested Citation

  • Yang Zhang & Xiaoyong Wang & Chengchao Chu & Zijian Zhou & Biaoqi Chen & Xin Pang & Gan Lin & Huirong Lin & Yuxin Guo & En Ren & Peng Lv & Yesi Shi & Qingbing Zheng & Xiaohui Yan & Xiaoyuan Chen & Gan, 2020. "Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19061-9
    DOI: 10.1038/s41467-020-19061-9
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    Cited by:

    1. Alexandre Fromain & Jose Efrain Perez & Aurore Van de Walle & Yoann Lalatonne & Claire Wilhelm, 2023. "Photothermia at the nanoscale induces ferroptosis via nanoparticle degradation," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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