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Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion

Author

Listed:
  • Bianca Cioni

    (Divisions of Oncogenomics, The Netherlands Cancer Institute (NKI))

  • Anniek Zaalberg

    (Divisions of Oncogenomics, The Netherlands Cancer Institute (NKI))

  • Judy R. Beijnum

    (Angiogenesis laboratory, Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam)

  • Monique H. M. Melis

    (Molecular Genetics, NKI)

  • Johan Burgsteden

    (Molecular Genetics, NKI)

  • Mauro J. Muraro

    (Hubrecht Institute - KNAW and University Medical Center Utrecht)

  • Erik Hooijberg

    (Division of Pathology, NKI)

  • Dennis Peters

    (Core Facility Molecular Pathology, NKI)

  • Ingrid Hofland

    (Core Facility Molecular Pathology, NKI)

  • Yoni Lubeck

    (Division of Pathology, NKI)

  • Jeroen Jong

    (Division of Pathology, NKI)

  • Joyce Sanders

    (Division of Pathology, NKI)

  • Judith Vivié

    (Hubrecht Institute - KNAW and University Medical Center Utrecht)

  • Henk G. Poel

    (Urology and Medical Oncology, NKI)

  • Jan Paul Boer

    (Urology and Medical Oncology, NKI)

  • Arjan W. Griffioen

    (Angiogenesis laboratory, Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam)

  • Wilbert Zwart

    (Divisions of Oncogenomics, The Netherlands Cancer Institute (NKI)
    Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology)

  • Andries M. Bergman

    (Divisions of Oncogenomics, The Netherlands Cancer Institute (NKI)
    Urology and Medical Oncology, NKI)

Abstract

The androgen receptor (AR) is the master regulator of prostate cancer (PCa) development, and inhibition of AR signalling is the most effective PCa treatment. AR is expressed in PCa cells and also in the PCa-associated stroma, including infiltrating macrophages. Macrophages have a decisive function in PCa initiation and progression, but the role of AR in macrophages remains largely unexplored. Here, we show that AR signalling in the macrophage-like THP-1 cell line supports PCa cell line migration and invasion in culture via increased Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) signalling and expression of its downstream cytokines. Moreover, AR signalling in THP-1 and monocyte-derived macrophages upregulates IL-10 and markers of tissue residency. In conclusion, our data suggest that AR signalling in macrophages may support PCa invasiveness, and blocking this process may constitute one mechanism of anti-androgen therapy.

Suggested Citation

  • Bianca Cioni & Anniek Zaalberg & Judy R. Beijnum & Monique H. M. Melis & Johan Burgsteden & Mauro J. Muraro & Erik Hooijberg & Dennis Peters & Ingrid Hofland & Yoni Lubeck & Jeroen Jong & Joyce Sander, 2020. "Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18313-y
    DOI: 10.1038/s41467-020-18313-y
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    Cited by:

    1. Judy R. Beijnum & Elisabeth J. M. Huijbers & Karlijn Loon & Athanasios Blanas & Parvin Akbari & Arno Roos & Tse J. Wong & Stepan S. Denisov & Tilman M. Hackeng & Connie R. Jimenez & Patrycja Nowak-Sli, 2022. "Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Jeroen Kneppers & Tesa M. Severson & Joseph C. Siefert & Pieter Schol & Stacey E. P. Joosten & Ivan Pak Lok Yu & Chia-Chi Flora Huang & Tunç Morova & Umut Berkay Altıntaş & Claudia Giambartolomei & Ji, 2022. "Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Renee E. Vickman & LaTayia Aaron-Brooks & Renyuan Zhang & Nadia A. Lanman & Brittany Lapin & Victoria Gil & Max Greenberg & Takeshi Sasaki & Gregory M. Cresswell & Meaghan M. Broman & J. Sebastian Pae, 2022. "TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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