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Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

Author

Listed:
  • Rui Wang

    (Wuhan University
    Wuhan University)

  • Miusi Shi

    (Wuhan University)

  • Feiyan Xu

    (Xianhu Hydrogen Valley
    Wuhan University of Technology)

  • Yun Qiu

    (Wuhan University)

  • Peng Zhang

    (Wuhan University)

  • Kailun Shen

    (Wuhan University)

  • Qin Zhao

    (Wuhan University)

  • Jiaguo Yu

    (Xianhu Hydrogen Valley
    Wuhan University of Technology)

  • Yufeng Zhang

    (Wuhan University
    Wuhan University)

Abstract

Titanium implants have been widely used in bone tissue engineering for decades. However, orthopedic implant-associated infections increase the risk of implant failure and even lead to amputation in severe cases. Although TiO2 has photocatalytic activity to produce reactive oxygen species (ROS), the recombination of generated electrons and holes limits its antibacterial ability. Here, we describe a graphdiyne (GDY) composite TiO2 nanofiber that combats implant infections through enhanced photocatalysis and prolonged antibacterial ability. In addition, GDY-modified TiO2 nanofibers exert superior biocompatibility and osteoinductive abilities for cell adhesion and differentiation, thus contributing to the bone tissue regeneration process in drug-resistant bacteria-induced implant infection.

Suggested Citation

  • Rui Wang & Miusi Shi & Feiyan Xu & Yun Qiu & Peng Zhang & Kailun Shen & Qin Zhao & Jiaguo Yu & Yufeng Zhang, 2020. "Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18267-1
    DOI: 10.1038/s41467-020-18267-1
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    Cited by:

    1. Jin, Zhiliang & Jiang, Xudong & Liu, Yanan, 2022. "Graphdiyne(CnH2n-2) based NiS S-scheme heterojunction for efficient photocatalytic hydrogen production," Renewable Energy, Elsevier, vol. 201(P1), pages 854-863.
    2. Yanli Huang & Xufeng Wan & Qiang Su & Chunlin Zhao & Jian Cao & Yan Yue & Shuoyuan Li & Xiaoting Chen & Jie Yin & Yi Deng & Xianzeng Zhang & Tianmin Wu & Zongke Zhou & Duan Wang, 2024. "Ultrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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