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Origin and function of the yolk sac in primate embryogenesis

Author

Listed:
  • Connor Ross

    (University of Cambridge
    University of Cambridge, Jeffrey Cheah Biomedical Centre)

  • Thorsten E. Boroviak

    (University of Cambridge
    University of Cambridge, Jeffrey Cheah Biomedical Centre
    University of Cambridge)

Abstract

Human embryogenesis is hallmarked by two phases of yolk sac development. The primate hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a secondary yolk sac during gastrulation. Moreover, primate embryos form extraembryonic mesoderm prior to gastrulation, in contrast to mouse. The function of the primary yolk sac and the origin of extraembryonic mesoderm remain unclear. Here, we hypothesise that the hypoblast-derived primary yolk sac serves as a source for early extraembryonic mesoderm, which is supplemented with mesoderm from the gastrulating embryo. We discuss the intricate relationship between the yolk sac and the primate embryo and highlight the pivotal role of the yolk sac as a multifunctional hub for haematopoiesis, germ cell development and nutritional supply.

Suggested Citation

  • Connor Ross & Thorsten E. Boroviak, 2020. "Origin and function of the yolk sac in primate embryogenesis," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17575-w
    DOI: 10.1038/s41467-020-17575-w
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    Cited by:

    1. Anna Malkowska & Christopher Penfold & Sophie Bergmann & Thorsten E. Boroviak, 2022. "A hexa-species transcriptome atlas of mammalian embryogenesis delineates metabolic regulation across three different implantation modes," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Mingyue Guo & Jinyi Wu & Chuanxin Chen & Xinggu Wang & An Gong & Wei Guan & Rowan M. Karvas & Kexin Wang & Mingwei Min & Yixuan Wang & Thorold W. Theunissen & Shaorong Gao & José C. R. Silva, 2024. "Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Zhengfang Chen & Mudan He & Houpeng Wang & Xuehui Li & Ruirui Qin & Ding Ye & Xue Zhai & Junwen Zhu & Quanqing Zhang & Peng Hu & Guanghou Shui & Yonghua Sun, 2024. "Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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