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Single-atom Ni-N4 provides a robust cellular NO sensor

Author

Listed:
  • Min Zhou

    (Capital Normal University
    the Chinese Academy of Sciences (CAS))

  • Ying Jiang

    (Beijing Normal University)

  • Guo Wang

    (Capital Normal University)

  • Wenjie Wu

    (the Chinese Academy of Sciences (CAS)
    Anhui Normal University)

  • Wenxing Chen

    (Beijing Institute of Technology)

  • Ping Yu

    (the Chinese Academy of Sciences (CAS)
    University of Chinese Academy of Sciences)

  • Yuqing Lin

    (Capital Normal University)

  • Junjie Mao

    (Anhui Normal University)

  • Lanqun Mao

    (the Chinese Academy of Sciences (CAS)
    University of Chinese Academy of Sciences)

Abstract

Nitric oxide (NO) has been implicated in a variety of physiological and pathological processes. Monitoring cellular levels of NO requires a sensor to feature adequate sensitivity, transient recording ability and biocompatibility. Herein we report a single-atom catalysts (SACs)-based electrochemical sensor for the detection of NO in live cellular environment. The system employs nickel single atoms anchored on N-doped hollow carbon spheres (Ni SACs/N-C) that act as an excellent catalyst for electrochemical oxidation of NO. Notably, Ni SACs/N-C shows superior electrocatalytic performance to the commonly used Ni based nanomaterials, attributing from the greatly reduced Gibbs free energy that are required for Ni SACs/N-C in activating NO oxidation. Moreover, Ni SACs-based flexible and stretchable sensor shows high biocompatibility and low nanomolar sensitivity, enabling the real-time monitoring of NO release from cells upon drug and stretch stimulation. Our results demonstrate a promising means of using SACs for electrochemical sensing applications.

Suggested Citation

  • Min Zhou & Ying Jiang & Guo Wang & Wenjie Wu & Wenxing Chen & Ping Yu & Yuqing Lin & Junjie Mao & Lanqun Mao, 2020. "Single-atom Ni-N4 provides a robust cellular NO sensor," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17018-6
    DOI: 10.1038/s41467-020-17018-6
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    Cited by:

    1. Junjie Li & Ya-fei Jiang & Qi Wang & Cong-Qiao Xu & Duojie Wu & Mohammad Norouzi Banis & Keegan R. Adair & Kieran Doyle-Davis & Debora Motta Meira & Y. Zou Finfrock & Weihan Li & Lei Zhang & Tsun-Kong, 2021. "A general strategy for preparing pyrrolic-N4 type single-atom catalysts via pre-located isolated atoms," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Shuo Zhang & Jianghua Wu & Mengting Zheng & Xin Jin & Zihan Shen & Zhonghua Li & Yanjun Wang & Quan Wang & Xuebin Wang & Hui Wei & Jiangwei Zhang & Peng Wang & Shanqing Zhang & Liyan Yu & Lifeng Dong , 2023. "Fe/Cu diatomic catalysts for electrochemical nitrate reduction to ammonia," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Xiaolong Gao & Huan Wei & Wenjie Ma & Wenjie Wu & Wenliang Ji & Junjie Mao & Ping Yu & Lanqun Mao, 2024. "Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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