IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-17018-6.html
   My bibliography  Save this article

Single-atom Ni-N4 provides a robust cellular NO sensor

Author

Listed:
  • Min Zhou

    (Capital Normal University
    the Chinese Academy of Sciences (CAS))

  • Ying Jiang

    (Beijing Normal University)

  • Guo Wang

    (Capital Normal University)

  • Wenjie Wu

    (the Chinese Academy of Sciences (CAS)
    Anhui Normal University)

  • Wenxing Chen

    (Beijing Institute of Technology)

  • Ping Yu

    (the Chinese Academy of Sciences (CAS)
    University of Chinese Academy of Sciences)

  • Yuqing Lin

    (Capital Normal University)

  • Junjie Mao

    (Anhui Normal University)

  • Lanqun Mao

    (the Chinese Academy of Sciences (CAS)
    University of Chinese Academy of Sciences)

Abstract

Nitric oxide (NO) has been implicated in a variety of physiological and pathological processes. Monitoring cellular levels of NO requires a sensor to feature adequate sensitivity, transient recording ability and biocompatibility. Herein we report a single-atom catalysts (SACs)-based electrochemical sensor for the detection of NO in live cellular environment. The system employs nickel single atoms anchored on N-doped hollow carbon spheres (Ni SACs/N-C) that act as an excellent catalyst for electrochemical oxidation of NO. Notably, Ni SACs/N-C shows superior electrocatalytic performance to the commonly used Ni based nanomaterials, attributing from the greatly reduced Gibbs free energy that are required for Ni SACs/N-C in activating NO oxidation. Moreover, Ni SACs-based flexible and stretchable sensor shows high biocompatibility and low nanomolar sensitivity, enabling the real-time monitoring of NO release from cells upon drug and stretch stimulation. Our results demonstrate a promising means of using SACs for electrochemical sensing applications.

Suggested Citation

  • Min Zhou & Ying Jiang & Guo Wang & Wenjie Wu & Wenxing Chen & Ping Yu & Yuqing Lin & Junjie Mao & Lanqun Mao, 2020. "Single-atom Ni-N4 provides a robust cellular NO sensor," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17018-6
    DOI: 10.1038/s41467-020-17018-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-17018-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-17018-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Junjie Li & Ya-fei Jiang & Qi Wang & Cong-Qiao Xu & Duojie Wu & Mohammad Norouzi Banis & Keegan R. Adair & Kieran Doyle-Davis & Debora Motta Meira & Y. Zou Finfrock & Weihan Li & Lei Zhang & Tsun-Kong, 2021. "A general strategy for preparing pyrrolic-N4 type single-atom catalysts via pre-located isolated atoms," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Shuo Zhang & Jianghua Wu & Mengting Zheng & Xin Jin & Zihan Shen & Zhonghua Li & Yanjun Wang & Quan Wang & Xuebin Wang & Hui Wei & Jiangwei Zhang & Peng Wang & Shanqing Zhang & Liyan Yu & Lifeng Dong , 2023. "Fe/Cu diatomic catalysts for electrochemical nitrate reduction to ammonia," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17018-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.