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Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis

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Listed:
  • Karla J. Suchacki

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Adriana A. S. Tavares

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Domenico Mattiucci

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
    Università Politecnica delle Marche)

  • Erica L. Scheller

    (Washington University)

  • Giorgos Papanastasiou

    (Edinburgh Imaging, University of Edinburgh)

  • Calum Gray

    (Edinburgh Imaging, University of Edinburgh)

  • Matthew C. Sinton

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Lynne E. Ramage

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Wendy A. McDougald

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Andrea Lovdel

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Richard J. Sulston

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Benjamin J. Thomas

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Bonnie M. Nicholson

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Amanda J. Drake

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Carlos J. Alcaide-Corral

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Diana Said

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Antonella Poloni

    (Università Politecnica delle Marche)

  • Saverio Cinti

    (Università Politecnica delle Marche
    Università Politecnica delle Marche)

  • Gavin J. Macpherson

    (Royal Infirmary of Edinburgh)

  • Marc R. Dweck

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Jack P. M. Andrews

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Michelle C. Williams

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Robert J. Wallace

    (The University of Edinburgh)

  • Edwin J. R. Beek

    (Edinburgh Imaging, University of Edinburgh)

  • Ormond A. MacDougald

    (University of Michigan)

  • Nicholas M. Morton

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • Roland H. Stimson

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

  • William P. Cawthorn

    (University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter)

Abstract

Bone marrow adipose tissue (BMAT) comprises >10% of total adipose mass, yet unlike white or brown adipose tissues (WAT or BAT) its metabolic functions remain unclear. Herein, we address this critical gap in knowledge. Our transcriptomic analyses revealed that BMAT is distinct from WAT and BAT, with altered glucose metabolism and decreased insulin responsiveness. We therefore tested these functions in mice and humans using positron emission tomography-computed tomography (PET/CT) with 18F-fluorodeoxyglucose. This revealed that BMAT resists insulin- and cold-stimulated glucose uptake, while further in vivo studies showed that, compared to WAT, BMAT resists insulin-stimulated Akt phosphorylation. Thus, BMAT is functionally distinct from WAT and BAT. However, in humans basal glucose uptake in BMAT is greater than in axial bones or subcutaneous WAT and can be greater than that in skeletal muscle, underscoring the potential of BMAT to influence systemic glucose homeostasis. These PET/CT studies characterise BMAT function in vivo, establish new methods for BMAT analysis, and identify BMAT as a distinct, major adipose tissue subtype.

Suggested Citation

  • Karla J. Suchacki & Adriana A. S. Tavares & Domenico Mattiucci & Erica L. Scheller & Giorgos Papanastasiou & Calum Gray & Matthew C. Sinton & Lynne E. Ramage & Wendy A. McDougald & Andrea Lovdel & Ric, 2020. "Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis," Nature Communications, Nature, vol. 11(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16878-2
    DOI: 10.1038/s41467-020-16878-2
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    Cited by:

    1. Tammy Liu & Gerd Melkus & Tim Ramsay & Adnan Sheikh & Odette Laneuville & Guy Trudel, 2023. "Bone marrow adiposity modulation after long duration spaceflight in astronauts," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Tongling Huang & Zhaocheng Lu & Zihui Wang & Lixin Cheng & Lu Gao & Jun Gao & Ning Zhang & Chang-An Geng & Xiaoli Zhao & Huaiyu Wang & Chi-Wai Wong & Kelvin W. K. Yeung & Haobo Pan & William Weijia Lu, 2024. "Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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