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Cell size sets the diameter of the budding yeast contractile ring

Author

Listed:
  • I. V. Kukhtevich

    (Helmholtz Zentrum München)

  • N. Lohrberg

    (Helmholtz Zentrum München)

  • F. Padovani

    (Helmholtz Zentrum München)

  • R. Schneider

    (Helmholtz Zentrum München
    German Center for Diabetes Research (DZD))

  • K. M. Schmoller

    (Helmholtz Zentrum München
    German Center for Diabetes Research (DZD))

Abstract

The formation and maintenance of subcellular structures and organelles with a well-defined size is a key requirement for cell function, yet our understanding of the underlying size control mechanisms is limited. While budding yeast cell polarization and subsequent assembly of a septin ring at the site of bud formation has been successfully used as a model for biological self-assembly processes, the mechanisms that set the size of the septin ring at the bud neck are unknown. Here, we use live-cell imaging and genetic manipulation of cell volume to show that the septin ring diameter increases with cell volume. This cell-volume-dependence largely accounts for modulations of ring size due to changes in ploidy and genetic manipulation of cell polarization. Our findings suggest that the ring diameter is set through the dynamic interplay of septin recruitment and Cdc42 polarization, establishing it as a model for size homeostasis of self-assembling organelles.

Suggested Citation

  • I. V. Kukhtevich & N. Lohrberg & F. Padovani & R. Schneider & K. M. Schmoller, 2020. "Cell size sets the diameter of the budding yeast contractile ring," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16764-x
    DOI: 10.1038/s41467-020-16764-x
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    Cited by:

    1. Hui Liu & Pei Zhou & Mengya Qi & Liang Guo & Cong Gao & Guipeng Hu & Wei Song & Jing Wu & Xiulai Chen & Jian Chen & Wei Chen & Liming Liu, 2022. "Enhancing biofuels production by engineering the actin cytoskeleton in Saccharomyces cerevisiae," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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