IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-16256-y.html
   My bibliography  Save this article

A human monoclonal antibody blocking SARS-CoV-2 infection

Author

Listed:
  • Chunyan Wang

    (Utrecht University)

  • Wentao Li

    (Utrecht University)

  • Dubravka Drabek

    (Erasmus Medical Center
    Harbour BioMed)

  • Nisreen M. A. Okba

    (Erasmus Medical Center)

  • Rien Haperen

    (Erasmus Medical Center
    Harbour BioMed)

  • Albert D. M. E. Osterhaus

    (University of Veterinary Medicine)

  • Frank J. M. Kuppeveld

    (Utrecht University)

  • Bart L. Haagmans

    (Erasmus Medical Center)

  • Frank Grosveld

    (Erasmus Medical Center
    Harbour BioMed)

  • Berend-Jan Bosch

    (Utrecht University)

Abstract

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.

Suggested Citation

  • Chunyan Wang & Wentao Li & Dubravka Drabek & Nisreen M. A. Okba & Rien Haperen & Albert D. M. E. Osterhaus & Frank J. M. Kuppeveld & Bart L. Haagmans & Frank Grosveld & Berend-Jan Bosch, 2020. "A human monoclonal antibody blocking SARS-CoV-2 infection," Nature Communications, Nature, vol. 11(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16256-y
    DOI: 10.1038/s41467-020-16256-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-16256-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-16256-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Erkin Kuru & Jonathan Rittichier & Helena Puig & Allison Flores & Subhrajit Rout & Isaac Han & Abigail E. Reese & Thomas M. Bartlett & Fabio Moliner & Sylvie G. Bernier & Jason D. Galpin & Jorge March, 2024. "Rapid discovery and evolution of nanosensors containing fluorogenic amino acids," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Niels Joachim Gormsen & Ralph S J Koijen & Nikolai Roussanov, 0. "Coronavirus: Impact on Stock Prices and Growth Expectations," The Review of Asset Pricing Studies, Society for Financial Studies, vol. 10(4), pages 574-597.
    3. Yifan Wang & Caixuan Liu & Chao Zhang & Yanxing Wang & Qin Hong & Shiqi Xu & Zuyang Li & Yong Yang & Zhong Huang & Yao Cong, 2022. "Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Safiyanu, Babangida Danladi & Isa, Musa & Lawan, Isah Isah, 2020. "Impact of COVID-19 on the Nigerian Stock Exchange Market," MPRA Paper 110408, University Library of Munich, Germany.
    5. Franziska K. Kaiser & Mariana Gonzalez Hernandez & Nadine Krüger & Ellinor Englund & Wenjuan Du & Anna Z. Mykytyn & Mathijs P. Raadsen & Mart M. Lamers & Francine Rodrigues Ianiski & Tatiana M. Shamor, 2024. "Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Chunyan Wang & Emma L. Hesketh & Tatiana M. Shamorkina & Wentao Li & Peter J. Franken & Dubravka Drabek & Rien Haperen & Sarah Townend & Frank J. M. Kuppeveld & Frank Grosveld & Neil A. Ranson & Joost, 2022. "Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    7. P. K. Mishra & S. K. Mishra, 2020. "Corona Pandemic and Stock Market Behaviour: Empirical Insights from Selected Asian Countries," Millennial Asia, , vol. 11(3), pages 341-365, December.
    8. Lei Peng & Yingxia Hu & Madeleine C. Mankowski & Ping Ren & Rita E. Chen & Jin Wei & Min Zhao & Tongqing Li & Therese Tripler & Lupeng Ye & Ryan D. Chow & Zhenhao Fang & Chunxiang Wu & Matthew B. Dong, 2022. "Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16256-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.