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The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

Author

Listed:
  • Robert Verity

    (Imperial College London)

  • Ozkan Aydemir

    (Warren Alpert Medical School, Brown University)

  • Nicholas F. Brazeau

    (University of North Carolina)

  • Oliver J. Watson

    (Imperial College London)

  • Nicholas J. Hathaway

    (University of Massachusetts)

  • Melchior Kashamuka Mwandagalirwa

    (Hôpital Général Provincial de Référence de Kinshasa)

  • Patrick W. Marsh

    (Warren Alpert Medical School, Brown University)

  • Kyaw Thwai

    (University of North Carolina)

  • Travis Fulton

    (University of North Carolina at Chapel Hill)

  • Madeline Denton

    (University of North Carolina at Chapel Hill)

  • Andrew P. Morgan

    (University of North Carolina at Chapel Hill)

  • Jonathan B. Parr

    (University of North Carolina at Chapel Hill)

  • Patrick K. Tumwebaze

    (Infectious Disease Research Collaboration)

  • Melissa Conrad

    (University of California- San Francisco)

  • Philip J. Rosenthal

    (University of California- San Francisco)

  • Deus S. Ishengoma

    (National Institute for Medical Research)

  • Jeremiah Ngondi

    (RTI International)

  • Julie Gutman

    (Malaria Branch, Center for Global Health, Centers for Disease Control)

  • Modest Mulenga

    (Tropical Disease Research Centre)

  • Douglas E. Norris

    (Johns Hopkins Bloomberg School of Public Health)

  • William J. Moss

    (Johns Hopkins Bloomberg School of Public Health)

  • Benedicta A. Mensah

    (University of Ghana)

  • James L. Myers-Hansen

    (University of Ghana)

  • Anita Ghansah

    (University of Ghana)

  • Antoinette K. Tshefu

    (Hôpital Général Provincial de Référence de Kinshasa)

  • Azra C. Ghani

    (Imperial College London)

  • Steven R. Meshnick

    (University of North Carolina)

  • Jeffrey A. Bailey

    (Warren Alpert Medical School, Brown University)

  • Jonathan J. Juliano

    (University of North Carolina
    University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

Abstract

The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC and samples from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool. We identify an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimethamine. Furthermore, we identify highly related parasites over large geographic distances, indicative of gene flow and migration. Our results are consistent with a background of isolation by distance combined with the effects of selection for antimalarial drug resistance. This study provides a high-resolution view of parasite genetic structure across a large country in Africa and provides a baseline to study how implementation programs may impact parasite populations.

Suggested Citation

  • Robert Verity & Ozkan Aydemir & Nicholas F. Brazeau & Oliver J. Watson & Nicholas J. Hathaway & Melchior Kashamuka Mwandagalirwa & Patrick W. Marsh & Kyaw Thwai & Travis Fulton & Madeline Denton & And, 2020. "The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15779-8
    DOI: 10.1038/s41467-020-15779-8
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    Cited by:

    1. Philipp Schwabl & Flavia Camponovo & Collette Clementson & Angela M. Early & Margaret Laws & David A. Forero-Peña & Oscar Noya & María Eugenia Grillet & Mathieu Vanhove & Frank Anthony & Kashana James, 2024. "Contrasting genomic epidemiology between sympatric Plasmodium falciparum and Plasmodium vivax populations," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Mariateresa Cesare & Mulenga Mwenda & Anna E. Jeffreys & Jacob Chirwa & Chris Drakeley & Kammerle Schneider & Brenda Mambwe & Karolina Glanz & Christina Ntalla & Manuela Carrasquilla & Silvia Portugal, 2024. "Flexible and cost-effective genomic surveillance of P. falciparum malaria with targeted nanopore sequencing," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Aurel Holzschuh & Anita Lerch & Inna Gerlovina & Bakar S. Fakih & Abdul-wahid H. Al-mafazy & Erik J. Reaves & Abdullah Ali & Faiza Abbas & Mohamed Haji Ali & Mohamed Ali Ali & Manuel W. Hetzel & Joshu, 2023. "Multiplexed ddPCR-amplicon sequencing reveals isolated Plasmodium falciparum populations amenable to local elimination in Zanzibar, Tanzania," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Patrick K. Tumwebaze & Melissa D. Conrad & Martin Okitwi & Stephen Orena & Oswald Byaruhanga & Thomas Katairo & Jennifer Legac & Shreeya Garg & David Giesbrecht & Sawyer R. Smith & Frida G. Ceja & Sam, 2022. "Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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