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Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Author

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  • Min Li

    (University of Science and Technology of China
    University of Science and Technology of China
    Shenzhen University)

  • Shuya Li

    (University of Science and Technology of China)

  • Han Zhou

    (University of Science and Technology of China)

  • Xinfeng Tang

    (University of Science and Technology of China)

  • Yi Wu

    (University of Science and Technology of China)

  • Wei Jiang

    (University of Science and Technology of China)

  • Zhigang Tian

    (University of Science and Technology of China)

  • Xuechang Zhou

    (Shenzhen University)

  • Xianzhu Yang

    (South China University of Technology)

  • Yucai Wang

    (University of Science and Technology of China
    University of Science and Technology of China)

Abstract

The efficacy of nano-mediated drug delivery has been impeded by multiple biological barriers such as the mononuclear phagocyte system (MPS), as well as vascular and interstitial barriers. To overcome the abovementioned obstacles, we report a nano-pathogenoid (NPN) system that can in situ hitchhike circulating neutrophils and supplement photothermal therapy (PTT). Cloaked with bacteria-secreted outer membrane vesicles inheriting pathogen-associated molecular patterns of native bacteria, NPNs are effectively recognized and internalized by neutrophils. The neutrophils migrate towards inflamed tumors, extravasate across the blood vessels, and penetrate through the tumors. Then NPNs are rapidly released from neutrophils in response to inflammatory stimuli and subsequently taken up by tumor cells to exert anticancer effects. Strikingly, due to the excellent targeting efficacy, cisplatin-loaded NPNs combined with PTT completely eradicate tumors in all treated mice. Such a nano-platform represents an efficient and generalizable strategy towards in situ cell hitchhiking as well as enhanced tumor targeted delivery.

Suggested Citation

  • Min Li & Shuya Li & Han Zhou & Xinfeng Tang & Yi Wu & Wei Jiang & Zhigang Tian & Xuechang Zhou & Xianzhu Yang & Yucai Wang, 2020. "Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14963-0
    DOI: 10.1038/s41467-020-14963-0
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    Cited by:

    1. Jinhu Liu & Huajun Zhao & Tong Gao & Xinyan Huang & Shujun Liu & Meichen Liu & Weiwei Mu & Shuang Liang & Shunli Fu & Shijun Yuan & Qinglin Yang & Panpan Gu & Nan Li & Qingping Ma & Jie Liu & Xinke Zh, 2024. "Glypican-3-targeted macrophages delivering drug-loaded exosomes offer efficient cytotherapy in mouse models of solid tumours," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Xin Li & Yong Hu & Xingcai Zhang & Xiangyang Shi & Wolfgang J. Parak & Andrij Pich, 2024. "Transvascular transport of nanocarriers for tumor delivery," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Xin Li & Tuying Yong & Zhaohan Wei & Nana Bie & Xiaoqiong Zhang & Guiting Zhan & Jianye Li & Jiaqi Qin & Jingjing Yu & Bixiang Zhang & Lu Gan & Xiangliang Yang, 2022. "Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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