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Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

Author

Listed:
  • Lijun Wang

    (University of Chinese Academy of Sciences)

  • Xiuling You

    (University of Chinese Academy of Sciences)

  • Sutada Lotinun

    (Chulalongkorn University)

  • Lingli Zhang

    (University of Chinese Academy of Sciences)

  • Nan Wu

    (Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Weiguo Zou

    (University of Chinese Academy of Sciences
    Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

Abstract

Wolff’s law and the Utah Paradigm of skeletal physiology state that bone architecture adapts to mechanical loads. These models predict the existence of a mechanostat that links strain induced by mechanical forces to skeletal remodeling. However, how the mechanostat influences bone remodeling remains elusive. Here, we find that Piezo1 deficiency in osteoblastic cells leads to loss of bone mass and spontaneous fractures with increased bone resorption. Furthermore, Piezo1-deficient mice are resistant to further bone loss and bone resorption induced by hind limb unloading, demonstrating that PIEZO1 can affect osteoblast-osteoclast crosstalk in response to mechanical forces. At the mechanistic level, in response to mechanical loads, PIEZO1 in osteoblastic cells controls the YAP-dependent expression of type II and IX collagens. In turn, these collagen isoforms regulate osteoclast differentiation. Taken together, our data identify PIEZO1 as the major skeletal mechanosensor that tunes bone homeostasis.

Suggested Citation

  • Lijun Wang & Xiuling You & Sutada Lotinun & Lingli Zhang & Nan Wu & Weiguo Zou, 2020. "Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-14146-6
    DOI: 10.1038/s41467-019-14146-6
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    Cited by:

    1. Maria Dzamukova & Tobias M. Brunner & Jadwiga Miotla-Zarebska & Frederik Heinrich & Laura Brylka & Mir-Farzin Mashreghi & Anjali Kusumbe & Ralf Kühn & Thorsten Schinke & Tonia L. Vincent & Max Löhning, 2022. "Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Alia M. Obeidat & Matthew J. Wood & Natalie S. Adamczyk & Shingo Ishihara & Jun Li & Lai Wang & Dongjun Ren & David A. Bennett & Richard J. Miller & Anne-Marie Malfait & Rachel E. Miller, 2023. "Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Hai-Bo Zhang & Xiao-Bao Ding & Jie Jin & Wen-Ping Guo & Qiao-Lei Yang & Peng-Cheng Chen & Heng Yao & Li Ruan & Yu-Tian Tao & Xin Chen, 2022. "Predicted mouse interactome and network-based interpretation of differentially expressed genes," PLOS ONE, Public Library of Science, vol. 17(4), pages 1-16, April.
    4. Nathalia G. Amado & Elena D. Nosyreva & David Thompson & Thomas J. Egeland & Osita W. Ogujiofor & Michelle Yang & Alexandria N. Fusco & Niccolo Passoni & Jeremy Mathews & Brandi Cantarel & Linda A. Ba, 2024. "PIEZO1 loss-of-function compound heterozygous mutations in the rare congenital human disorder Prune Belly Syndrome," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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