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Highly durable crack sensor integrated with silicone rubber cantilever for measuring cardiac contractility

Author

Listed:
  • Dong-Su Kim

    (Chonnam National University)

  • Yong Whan Choi

    (Silla University)

  • Arunkumar Shanmugasundaram

    (Chonnam National University)

  • Yun-Jin Jeong

    (Chonnam National University)

  • Jongsung Park

    (Chonnam National University)

  • Nomin-Erdene Oyunbaatar

    (Chonnam National University)

  • Eung-Sam Kim

    (Chonnam National University
    Chonnam National University)

  • Mansoo Choi

    (Seoul National University)

  • Dong-Weon Lee

    (Chonnam National University
    Chonnam National University)

Abstract

To date, numerous biosensing platforms have been developed for assessing drug-induced cardiac toxicity by measuring the change in contractile force of cardiomyocytes. However, these low sensitivity, low-throughput, and time-consuming processes are severely limited in their real-time applications. Here, we propose a cantilever device integrated with a polydimethylsiloxane (PDMS)-encapsulated crack sensor to measure cardiac contractility. The crack sensor is chemically bonded to a PDMS thin layer that allows it to be operated very stably in culture media. The reliability of the proposed crack sensor has been improved dramatically compared to no encapsulation layer. The highly sensitive crack sensor continuously measures the cardiac contractility without changing its gauge factor for up to 26 days (>5 million heartbeats), while changes in contractile force induced by drugs are monitored using the crack sensor-integrated cantilever. Finally, experimental results are compared with those obtained via conventional optical methods to verify the feasibility of building a contraction-based drug-toxicity testing system.

Suggested Citation

  • Dong-Su Kim & Yong Whan Choi & Arunkumar Shanmugasundaram & Yun-Jin Jeong & Jongsung Park & Nomin-Erdene Oyunbaatar & Eung-Sam Kim & Mansoo Choi & Dong-Weon Lee, 2020. "Highly durable crack sensor integrated with silicone rubber cantilever for measuring cardiac contractility," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-14019-y
    DOI: 10.1038/s41467-019-14019-y
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    Cited by:

    1. Qiwei Li & Zaozao Chen & Ying Zhang & Shuang Ding & Haibo Ding & Luping Wang & Zhuoying Xie & Yifu Fu & Mengxiao Wei & Shengnan Liu & Jialun Chen & Xuan Wang & Zhongze Gu, 2023. "Imaging cellular forces with photonic crystals," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Yang Liu & Zijun Xu & Xinyi Ji & Xin Xu & Fei Chen & Xiaosen Pan & Zhiqiang Fu & Yunzhi Chen & Zhengjian Zhang & Hongbin Liu & Bowen Cheng & Jiajie Liang, 2024. "Ag–thiolate interactions to enable an ultrasensitive and stretchable MXene strain sensor with high temporospatial resolution," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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