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Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid

Author

Listed:
  • Vasantha Basavalingappa

    (Tel Aviv University)

  • Santu Bera

    (Tel Aviv University)

  • Bin Xue

    (Nanjing University)

  • Ido Azuri

    (Weizmann Institute of Science)

  • Yiming Tang

    (Fudan University)

  • Kai Tao

    (Tel Aviv University)

  • Linda J. W. Shimon

    (Weizmann Institute of Science)

  • Michael R. Sawaya

    (University of California, Los Angeles)

  • Sofiya Kolusheva

    (Ben Gurion University of the Negev)

  • David S. Eisenberg

    (University of California, Los Angeles)

  • Leeor Kronik

    (Weizmann Institute of Science)

  • Yi Cao

    (Nanjing University)

  • Guanghong Wei

    (Fudan University)

  • Ehud Gazit

    (Tel Aviv University)

Abstract

The variety and complexity of DNA-based structures make them attractive candidates for nanotechnology, yet insufficient stability and mechanical rigidity, compared to polyamide-based molecules, limit their application. Here, we combine the advantages of polyamide materials and the structural patterns inspired by nucleic-acids to generate a mechanically rigid fluorenylmethyloxycarbonyl (Fmoc)-guanine peptide nucleic acid (PNA) conjugate with diverse morphology and photoluminescent properties. The assembly possesses a unique atomic structure, with each guanine head of one molecule hydrogen bonded to the Fmoc carbonyl tail of another molecule, generating a non-planar cyclic quartet arrangement. This structure exhibits an average stiffness of 69.6 ± 6.8 N m−1 and Young’s modulus of 17.8 ± 2.5 GPa, higher than any previously reported nucleic acid derived structure. This data suggests that the unique cation-free “basket” formed by the Fmoc-G-PNA conjugate can serve as an attractive component for the design of new materials based on PNA self-assembly for nanotechnology applications.

Suggested Citation

  • Vasantha Basavalingappa & Santu Bera & Bin Xue & Ido Azuri & Yiming Tang & Kai Tao & Linda J. W. Shimon & Michael R. Sawaya & Sofiya Kolusheva & David S. Eisenberg & Leeor Kronik & Yi Cao & Guanghong , 2019. "Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13250-x
    DOI: 10.1038/s41467-019-13250-x
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    Cited by:

    1. Shichao Xu & Haifeng Wu & Siyuan Liu & Peidong Du & Hui Wang & Haijun Yang & Wenjie Xu & Shuangming Chen & Li Song & Jikun Li & Xinghua Shi & Zhen-Gang Wang, 2023. "A supramolecular metalloenzyme possessing robust oxidase-mimetic catalytic function," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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