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Stem-cell-ubiquitous genes spatiotemporally coordinate division through regulation of stem-cell-specific gene networks

Author

Listed:
  • Natalie M. Clark

    (North Carolina State University
    North Carolina State University
    Iowa State University)

  • Eli Buckner

    (North Carolina State University)

  • Adam P. Fisher

    (North Carolina State University)

  • Emily C. Nelson

    (North Carolina State University)

  • Thomas T. Nguyen

    (North Carolina State University)

  • Abigail R. Simmons

    (Stanford University)

  • Maria A. Luis Balaguer

    (North Carolina State University)

  • Tiara Butler-Smith

    (North Carolina State University)

  • Parnell J. Sheldon

    (North Carolina State University
    Denison University)

  • Dominique C. Bergmann

    (Stanford University
    Stanford University)

  • Cranos M. Williams

    (North Carolina State University)

  • Rossangela Sozzani

    (North Carolina State University
    North Carolina State University)

Abstract

Stem cells are responsible for generating all of the differentiated cells, tissues, and organs in a multicellular organism and, thus, play a crucial role in cell renewal, regeneration, and organization. A number of stem cell type-specific genes have a known role in stem cell maintenance, identity, and/or division. Yet, how genes expressed across different stem cell types, referred to here as stem-cell-ubiquitous genes, contribute to stem cell regulation is less understood. Here, we find that, in the Arabidopsis root, a stem-cell-ubiquitous gene, TESMIN-LIKE CXC2 (TCX2), controls stem cell division by regulating stem cell-type specific networks. Development of a mathematical model of TCX2 expression allows us to show that TCX2 orchestrates the coordinated division of different stem cell types. Our results highlight that genes expressed across different stem cell types ensure cross-communication among cells, allowing them to divide and develop harmonically together.

Suggested Citation

  • Natalie M. Clark & Eli Buckner & Adam P. Fisher & Emily C. Nelson & Thomas T. Nguyen & Abigail R. Simmons & Maria A. Luis Balaguer & Tiara Butler-Smith & Parnell J. Sheldon & Dominique C. Bergmann & C, 2019. "Stem-cell-ubiquitous genes spatiotemporally coordinate division through regulation of stem-cell-specific gene networks," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13132-2
    DOI: 10.1038/s41467-019-13132-2
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    Cited by:

    1. Natalie M. Clark & Trevor M. Nolan & Ping Wang & Gaoyuan Song & Christian Montes & Conner T. Valentine & Hongqing Guo & Rosangela Sozzani & Yanhai Yin & Justin W. Walley, 2021. "Integrated omics networks reveal the temporal signaling events of brassinosteroid response in Arabidopsis," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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