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WUSCHEL acts as an auxin response rheostat to maintain apical stem cells in Arabidopsis

Author

Listed:
  • Yanfei Ma

    (Heidelberg University)

  • Andrej Miotk

    (Heidelberg University)

  • Zoran Šutiković

    (Heidelberg University)

  • Olga Ermakova

    (Heidelberg University)

  • Christian Wenzl

    (Heidelberg University)

  • Anna Medzihradszky

    (Heidelberg University)

  • Christophe Gaillochet

    (Heidelberg University)

  • Joachim Forner

    (Heidelberg University)

  • Gözde Utan

    (Heidelberg University)

  • Klaus Brackmann

    (Austrian Academy of Sciences)

  • Carlos S. Galván-Ampudia

    (University of Lyon, ENS de Lyon)

  • Teva Vernoux

    (University of Lyon, ENS de Lyon)

  • Thomas Greb

    (Heidelberg University)

  • Jan U. Lohmann

    (Heidelberg University)

Abstract

To maintain the balance between long-term stem cell self-renewal and differentiation, dynamic signals need to be translated into spatially precise and temporally stable gene expression states. In the apical plant stem cell system, local accumulation of the small, highly mobile phytohormone auxin triggers differentiation while at the same time, pluripotent stem cells are maintained throughout the entire life-cycle. We find that stem cells are resistant to auxin mediated differentiation, but require low levels of signaling for their maintenance. We demonstrate that the WUSCHEL transcription factor confers this behavior by rheostatically controlling the auxin signaling and response pathway. Finally, we show that WUSCHEL acts via regulation of histone acetylation at target loci, including those with functions in the auxin pathway. Our results reveal an important mechanism that allows cells to differentially translate a potent and highly dynamic developmental signal into stable cell behavior with high spatial precision and temporal robustness.

Suggested Citation

  • Yanfei Ma & Andrej Miotk & Zoran Šutiković & Olga Ermakova & Christian Wenzl & Anna Medzihradszky & Christophe Gaillochet & Joachim Forner & Gözde Utan & Klaus Brackmann & Carlos S. Galván-Ampudia & T, 2019. "WUSCHEL acts as an auxin response rheostat to maintain apical stem cells in Arabidopsis," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13074-9
    DOI: 10.1038/s41467-019-13074-9
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    Cited by:

    1. Guicai Cui & Yu Li & Leiying Zheng & Caroline Smith & Michael W. Bevan & Yunhai Li, 2024. "The peptidase DA1 cleaves and destabilizes WUSCHEL to control shoot apical meristem size," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Jian Zeng & Xin’Ai Zhao & Zhe Liang & Inés Hidalgo & Michael Gebert & Pengfei Fan & Christian Wenzl & Sebastian G. Gornik & Jan U. Lohmann, 2023. "Nitric oxide controls shoot meristem activity via regulation of DNA methylation," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Bihai Shi & Amelia Felipo-Benavent & Guillaume Cerutti & Carlos Galvan-Ampudia & Lucas Jilli & Geraldine Brunoud & Jérome Mutterer & Elody Vallet & Lali Sakvarelidze-Achard & Jean-Michel Davière & Ale, 2024. "A quantitative gibberellin signaling biosensor reveals a role for gibberellins in internode specification at the shoot apical meristem," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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