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The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity

Author

Listed:
  • Bo Li

    (Huazhong Agricultural University
    Huazhong Agricultural University)

  • Marco Aurélio Ferreira

    (National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
    Universidade Federal de Viçosa)

  • Mengling Huang

    (Huazhong Agricultural University
    Huazhong Agricultural University)

  • Luiz Fernando Camargos

    (National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
    Universidade Federal de Viçosa
    Science and Technology)

  • Xiao Yu

    (Texas A&M University)

  • Ruan M. Teixeira

    (National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
    Universidade Federal de Viçosa)

  • Paola A. Carpinetti

    (Universidade Federal de Viçosa)

  • Giselle C. Mendes

    (National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
    Universidade Federal de Viçosa
    Ciência e Tecnologia Catarinense)

  • Bianca C. Gouveia-Mageste

    (National Institute of Science and Technology in Plant–Pest Interactions, Bioagro)

  • Chenglong Liu

    (Texas A&M University)

  • Claudia S. L. Pontes

    (National Institute of Science and Technology in Plant–Pest Interactions, Bioagro)

  • Otávio J. B. Brustolini

    (National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
    Laboratório Nacional de Computação Cientifica (LNCC))

  • Laura G. C. Martins

    (National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
    Universidade Federal de Viçosa)

  • Bruno P. Melo

    (National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
    Universidade Federal de Viçosa)

  • Christiane E. M. Duarte

    (National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
    Universidade Federal de Viçosa)

  • Libo Shan

    (Texas A&M University)

  • Ping He

    (Texas A&M University)

  • Elizabeth P. B. Fontes

    (National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
    Universidade Federal de Viçosa)

Abstract

Plants deploy various immune receptors to recognize pathogens and defend themselves. Crosstalk may happen among receptor-mediated signal transduction pathways in the same host during simultaneous infection of different pathogens. However, the related function of the receptor-like kinases (RLKs) in thwarting different pathogens remains elusive. Here, we report that NIK1, which positively regulates plant antiviral immunity, acts as an important negative regulator of antibacterial immunity. nik1 plants exhibit dwarfed morphology, enhanced disease resistance to bacteria and increased PAMP-triggered immunity (PTI) responses, which are restored by NIK1 reintroduction. Additionally, NIK1 negatively regulates the formation of the FLS2/BAK1 complex. The interaction between NIK1 and FLS2/BAK1 is enhanced upon flg22 perception, revealing a novel PTI regulatory mechanism by an RLK. Furthermore, flg22 perception induces NIK1 and RPL10A phosphorylation in vivo, activating antiviral signalling. The NIK1-mediated inverse modulation of antiviral and antibacterial immunity may allow bacteria and viruses to activate host immune responses against each other.

Suggested Citation

  • Bo Li & Marco Aurélio Ferreira & Mengling Huang & Luiz Fernando Camargos & Xiao Yu & Ruan M. Teixeira & Paola A. Carpinetti & Giselle C. Mendes & Bianca C. Gouveia-Mageste & Chenglong Liu & Claudia S., 2019. "The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12847-6
    DOI: 10.1038/s41467-019-12847-6
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    Cited by:

    1. Changxuan Xia & Guohua Liang & Kang Chong & Yunyuan Xu, 2023. "The COG1-OsSERL2 complex senses cold to trigger signaling network for chilling tolerance in japonica rice," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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