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Stiffness-switchable DNA-based constitutional dynamic network hydrogels for self-healing and matrix-guided controlled chemical processes

Author

Listed:
  • Liang Yue

    (The Hebrew University of Jerusalem)

  • Shan Wang

    (The Hebrew University of Jerusalem)

  • Verena Wulf

    (The Hebrew University of Jerusalem)

  • Itamar Willner

    (The Hebrew University of Jerusalem)

Abstract

Constitutional dynamic networks (CDNs) attract interest as signal-triggered reconfigurable systems mimicking natural networks. The application of CDNs to control material properties is, however, a major challenge. Here we report on the design of a CDN consisting of four toehold-modified constituents, two of which act as bidentate units for chain-elongating, while the other two form a tetradentate structure acting as a crosslinking unit. Their hybridization yields a hydrogel of medium stiffness controlled by the balance between bidentate and tetradentate units. Stabilization of the tetradentate constituent by an auxiliary effector up-regulates the crosslinking unit, yielding a high-stiffness hydrogel. Conversely, stabilization of one of the bidentate constituents by an orthogonal effector enriches the chain-elongation units leading to a low-stiffness hydrogel. Using appropriate counter effectors, the hydrogels are reversibly switched across low-, medium- and high-stiffness states. The hydrogels are used to develop self-healing and controlled drug-release matrices and functional materials for operating biocatalytic cascades.

Suggested Citation

  • Liang Yue & Shan Wang & Verena Wulf & Itamar Willner, 2019. "Stiffness-switchable DNA-based constitutional dynamic network hydrogels for self-healing and matrix-guided controlled chemical processes," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12697-2
    DOI: 10.1038/s41467-019-12697-2
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    Cited by:

    1. Jianbang Wang & Zhenzhen Li & Itamar Willner, 2022. "Cascaded dissipative DNAzyme-driven layered networks guide transient replication of coded-strands as gene models," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Siddharth Agarwal & Dino Osmanovic & Mahdi Dizani & Melissa A. Klocke & Elisa Franco, 2024. "Dynamic control of DNA condensation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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