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Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis

Author

Listed:
  • C. S. Gallagher

    (Harvard Medical School)

  • N. Mäkinen

    (Harvard Medical School)

  • H. R. Harris

    (Fred Hutchinson Cancer Research Center)

  • N. Rahmioglu

    (University of Oxford)

  • O. Uimari

    (University of Oxford, John Radcliffe Hospital
    University of Oulu and Oulu University Hospital)

  • J. P. Cook

    (University of Liverpool)

  • N. Shigesi

    (University of Oxford, John Radcliffe Hospital)

  • T. Ferreira

    (University of Oxford
    Oxford University)

  • D. R. Velez-Edwards

    (Vanderbilt University Medical Center)

  • T. L. Edwards

    (Vanderbilt University Medical Center)

  • S. Mortlock

    (University of Queensland)

  • Z. Ruhioglu

    (Harvard Medical School)

  • F. Day

    (University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus)

  • C. M. Becker

    (University of Oxford, John Radcliffe Hospital)

  • V. Karhunen

    (University of Oulu
    Oulu University Hospital
    Imperial College London)

  • H. Martikainen

    (University of Oulu and Oulu University Hospital)

  • M.-R. Järvelin

    (University of Oulu
    Oulu University Hospital
    Imperial College London
    University of Oulu)

  • R. M. Cantor

    (University of California at Los Angeles)

  • P. M. Ridker

    (Harvard Medical School)

  • K. L. Terry

    (Brigham and Women’s Hospital and Harvard Medical School
    Harvard T.H. Chan School of Public Health)

  • J. E. Buring

    (Harvard Medical School)

  • S. D. Gordon

    (QIMR Berghofer Medical Research Institute)

  • S. E. Medland

    (QIMR Berghofer Medical Research Institute)

  • G. W. Montgomery

    (University of Queensland
    QIMR Berghofer Medical Research Institute)

  • D. R. Nyholt

    (QIMR Berghofer Medical Research Institute
    Queensland University of Technology)

  • D. A. Hinds

    (23andMe)

  • J. Y. Tung

    (23andMe)

  • J. R. B. Perry

    (University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus)

  • P. A. Lind

    (QIMR Berghofer Medical Research Institute)

  • J. N. Painter

    (QIMR Berghofer Medical Research Institute)

  • N. G. Martin

    (QIMR Berghofer Medical Research Institute)

  • A. P. Morris

    (University of Oxford
    University of Liverpool)

  • D. I. Chasman

    (Harvard Medical School)

  • S. A. Missmer

    (Harvard T.H. Chan School of Public Health
    Michigan State University)

  • K. T. Zondervan

    (University of Oxford
    University of Oxford, John Radcliffe Hospital)

  • C. C. Morton

    (Harvard Medical School
    Harvard Medical School
    Broad Institute of MIT and Harvard
    University of Manchester)

Abstract

Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying eight novel genome-wide significant (P

Suggested Citation

  • C. S. Gallagher & N. Mäkinen & H. R. Harris & N. Rahmioglu & O. Uimari & J. P. Cook & N. Shigesi & T. Ferreira & D. R. Velez-Edwards & T. L. Edwards & S. Mortlock & Z. Ruhioglu & F. Day & C. M. Becker, 2019. "Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12536-4
    DOI: 10.1038/s41467-019-12536-4
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    Citations

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    Cited by:

    1. Kadir Buyukcelebi & Alexander J. Duval & Fatih Abdula & Hoda Elkafas & Fidan Seker-Polat & Mazhar Adli, 2024. "Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Eeva Sliz & Jaakko S. Tyrmi & Nilufer Rahmioglu & Krina T. Zondervan & Christian M. Becker & Outi Uimari & Johannes Kettunen, 2023. "Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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