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Surface-kinetics mediated mesoporous multipods for enhanced bacterial adhesion and inhibition

Author

Listed:
  • Tiancong Zhao

    (Fudan University)

  • Liang Chen

    (Fudan University)

  • Peiyuan Wang

    (Fudan University)

  • Benhao Li

    (Fudan University)

  • Runfeng Lin

    (Fudan University)

  • Areej Abdulkareem Al-Khalaf

    (Princess Nourah Bint Abdulrahman University)

  • Wael N. Hozzein

    (King Saud University
    Beni-Suef University)

  • Fan Zhang

    (Fudan University)

  • Xiaomin Li

    (Fudan University)

  • Dongyuan Zhao

    (Fudan University)

Abstract

Despite the importance of nanoparticle’s multipods topology in multivalent-interactions enhanced nano-bio interactions, the precise manipulation of multipods surface topological structures is still a great challenge. Herein, the surface-kinetics mediated multi-site nucleation strategy is demonstrated for the fabrication of mesoporous multipods with precisely tunable surface topological structures. Tribulus-like tetra-pods Fe3O4@SiO2@RF&PMOs (RF = resorcinol-formaldehyde resin, PMO = periodic mesoporous organosilica) nanocomposites have successfully been fabricated with a centering core@shell Fe3O4@SiO2@RF nanoparticle, and four surrounding PMO nanocubes as pods. By manipulating the number of nucleation sites through mediating surface kinetics, a series of multipods mesoporous nanocomposites with precisely controllable surface topological structures are formed, including Janus with only one pod, nearly plane distributed dual-pods and tri-pods, three-dimensional tetrahedral structured tetra-pods, etc. The multipods topology endows the mesoporous nanocomposites enhanced bacteria adhesion ability. Particularly, the tribulus-like tetra-pods mesoporous nanoparticles show ~100% bacteria segregation and long-term inhibition over 90% after antibiotic loading.

Suggested Citation

  • Tiancong Zhao & Liang Chen & Peiyuan Wang & Benhao Li & Runfeng Lin & Areej Abdulkareem Al-Khalaf & Wael N. Hozzein & Fan Zhang & Xiaomin Li & Dongyuan Zhao, 2019. "Surface-kinetics mediated mesoporous multipods for enhanced bacterial adhesion and inhibition," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12378-0
    DOI: 10.1038/s41467-019-12378-0
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    Cited by:

    1. Yan Yu & Runfeng Lin & Hongyue Yu & Minchao Liu & Enyun Xing & Wenxing Wang & Fan Zhang & Dongyuan Zhao & Xiaomin Li, 2023. "Versatile synthesis of metal-compound based mesoporous Janus nanoparticles," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Yuzhu Ma & Hongjin Zhang & Runfeng Lin & Yan Ai & Kun Lan & Linlin Duan & Wenyao Chen & Xuezhi Duan & Bing Ma & Changyao Wang & Xiaomin Li & Dongyuan Zhao, 2022. "Remodeling nanodroplets into hierarchical mesoporous silica nanoreactors with multiple chambers," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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