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Structural puzzles in virology solved with an overarching icosahedral design principle

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  • Reidun Twarock

    (York Cross-disciplinary Centre for Systems Analysis, University of York)

  • Antoni Luque

    (Viral Information Institute, and Computational Science Research Center, San Diego State University)

Abstract

Viruses have evolved protein containers with a wide spectrum of icosahedral architectures to protect their genetic material. The geometric constraints defining these container designs, and their implications for viral evolution, are open problems in virology. The principle of quasi-equivalence is currently used to predict virus architecture, but improved imaging techniques have revealed increasing numbers of viral outliers. We show that this theory is a special case of an overarching design principle for icosahedral, as well as octahedral, architectures that can be formulated in terms of the Archimedean lattices and their duals. These surface structures encompass different blueprints for capsids with the same number of structural proteins, as well as for capsid architectures formed from a combination of minor and major capsid proteins, and are recurrent within viral lineages. They also apply to other icosahedral structures in nature, and offer alternative designs for man-made materials and nanocontainers in bionanotechnology.

Suggested Citation

  • Reidun Twarock & Antoni Luque, 2019. "Structural puzzles in virology solved with an overarching icosahedral design principle," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12367-3
    DOI: 10.1038/s41467-019-12367-3
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    Cited by:

    1. Nicola Bellomo & Richard Bingham & Mark A.J. Chaplain & Giovanni Dosi & Guido Forni & Damian A. Knopoff & John Lowengrub & Reidun Twarock & Maria Enrica Virgillito, 2020. "A multi-scale model of virus pandemic: Heterogeneous interactive entities in a globally connected world," LEM Papers Series 2020/16, Laboratory of Economics and Management (LEM), Sant'Anna School of Advanced Studies, Pisa, Italy.
    2. Jaekyung Hyun & Hideyuki Matsunami & Tae Gyun Kim & Matthias Wolf, 2022. "Assembly mechanism of the pleomorphic immature poxvirus scaffold," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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