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Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction

Author

Listed:
  • Aritra Bhattacherjee

    (Boston Children’s Hospital
    Boston Children’s Hospital
    Boston Children’s Hospital)

  • Mohamed Nadhir Djekidel

    (Boston Children’s Hospital
    Boston Children’s Hospital
    Boston Children’s Hospital)

  • Renchao Chen

    (Boston Children’s Hospital
    Boston Children’s Hospital
    Boston Children’s Hospital)

  • Wenqiang Chen

    (Boston Children’s Hospital
    Boston Children’s Hospital
    Boston Children’s Hospital)

  • Luis M. Tuesta

    (Boston Children’s Hospital
    Boston Children’s Hospital
    Boston Children’s Hospital)

  • Yi Zhang

    (Boston Children’s Hospital
    Boston Children’s Hospital
    Boston Children’s Hospital
    Harvard Medical School)

Abstract

Coordinated activity-induced transcriptional changes across multiple neuron subtypes of the prefrontal cortex (PFC) play a pivotal role in encoding and regulating major cognitive behaviors. Yet, the specific transcriptional programs in each neuron subtype remain unknown. Using single-cell RNA sequencing (scRNA-seq), here we comprehensively classify all unique cell subtypes in the PFC. We analyze transcriptional dynamics of each cell subtype under a naturally adaptive and an induced condition. Adaptive changes during adolescence (between P21 and P60), a highly dynamic phase of postnatal neuroplasticity, profoundly impacted transcription in each neuron subtype, including cell type-specific regulation of genes implicated in major neuropsychiatric disorders. On the other hand, an induced plasticity evoked by chronic cocaine addiction resulted in progressive transcriptional changes in multiple neuron subtypes and became most pronounced upon prolonged drug withdrawal. Our findings lay a foundation for understanding cell type-specific postnatal transcriptional dynamics under normal PFC function and in neuropsychiatric disease states.

Suggested Citation

  • Aritra Bhattacherjee & Mohamed Nadhir Djekidel & Renchao Chen & Wenqiang Chen & Luis M. Tuesta & Yi Zhang, 2019. "Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction," Nature Communications, Nature, vol. 10(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12054-3
    DOI: 10.1038/s41467-019-12054-3
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    Cited by:

    1. Gregory J. Salimando & Sébastien Tremblay & Blake A. Kimmey & Jia Li & Sophie A. Rogers & Jessica A. Wojick & Nora M. McCall & Lisa M. Wooldridge & Amrith Rodrigues & Tito Borner & Kristin L. Gardiner, 2023. "Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types," Nature Communications, Nature, vol. 14(1), pages 1-24, December.
    2. Kazuhiro Kon & Koji L. Ode & Tomoyuki Mano & Hiroshi Fujishima & Riina R. Takahashi & Daisuke Tone & Chika Shimizu & Shinnosuke Shiono & Saori Yada & Kyoko Matsuzawa & Shota Y. Yoshida & Junko Yoshida, 2024. "Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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