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The transferability of lipid loci across African, Asian and European cohorts

Author

Listed:
  • Karoline Kuchenbaecker

    (University College of London
    University College London
    Wellcome Sanger Institute)

  • Nikita Telkar

    (University College London)

  • Theresa Reiker

    (Wellcome Sanger Institute
    University of Cambridge
    Swiss Tropical and Public Health Institute
    University of Basel)

  • Robin G. Walters

    (University of Oxford
    University of Oxford)

  • Kuang Lin

    (University of Oxford)

  • Anders Eriksson

    (King’s College London)

  • Deepti Gurdasani

    (Wellcome Sanger Institute)

  • Arthur Gilly

    (Wellcome Sanger Institute
    German Research Center for Environmental Health)

  • Lorraine Southam

    (Wellcome Sanger Institute
    German Research Center for Environmental Health
    University of Oxford)

  • Emmanouil Tsafantakis

    (Anogia Medical Centre)

  • Maria Karaleftheri

    (Echinos Medical Centre, Echinos)

  • Janet Seeley

    (London School of Hygiene & Tropical Medicine
    London School of Hygiene & Tropical Medicine
    Uganda Research Unit)

  • Anatoli Kamali

    (Uganda Research Unit)

  • Gershim Asiki

    (Uganda Research Unit
    African Population and Health Research Center
    Karolinska Institutet)

  • Iona Y. Millwood

    (University of Oxford
    University of Oxford)

  • Michael Holmes

    (University of Oxford
    University of Oxford)

  • Huaidong Du

    (University of Oxford
    University of Oxford)

  • Yu Guo

    (Chinese Academy of Medical Sciences)

  • Meena Kumari

    (University of Essex)

  • George Dedoussis

    (Harokopio University of Athens)

  • Liming Li

    (School of Public Health, Peking University)

  • Zhengming Chen

    (University of Oxford)

  • Manjinder S. Sandhu

    (University of Cambridge)

  • Eleftheria Zeggini

    (Wellcome Sanger Institute
    German Research Center for Environmental Health)

Abstract

Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in samples from the UK, Uganda and Greece (r = 0.23–0.28, p

Suggested Citation

  • Karoline Kuchenbaecker & Nikita Telkar & Theresa Reiker & Robin G. Walters & Kuang Lin & Anders Eriksson & Deepti Gurdasani & Arthur Gilly & Lorraine Southam & Emmanouil Tsafantakis & Maria Karalefthe, 2019. "The transferability of lipid loci across African, Asian and European cohorts," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12026-7
    DOI: 10.1038/s41467-019-12026-7
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    Cited by:

    1. Qin Qin Huang & Neneh Sallah & Diana Dunca & Bhavi Trivedi & Karen A. Hunt & Sam Hodgson & Samuel A. Lambert & Elena Arciero & John Wright & Chris Griffiths & Richard C. Trembath & Harry Hemingway & M, 2022. "Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Isabelle Austin-Zimmerman & Daniel F. Levey & Olga Giannakopoulou & Joseph D. Deak & Marco Galimberti & Keyrun Adhikari & Hang Zhou & Spiros Denaxas & Haritz Irizar & Karoline Kuchenbaecker & Andrew M, 2023. "Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Abram Bunya Kamiza & Sounkou M. Touré & Feng Zhou & Opeyemi Soremekun & Cheickna Cissé & Mamadou Wélé & Aboubacrine M. Touré & Oyekanmi Nashiru & Manuel Corpas & Moffat Nyirenda & Amelia Crampin & Jef, 2023. "Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Ananyo Choudhury & Jean-Tristan Brandenburg & Tinashe Chikowore & Dhriti Sengupta & Palwende Romuald Boua & Nigel J. Crowther & Godfred Agongo & Gershim Asiki & F. Xavier Gómez-Olivé & Isaac Kisiangan, 2022. "Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Gemma Cadby & Corey Giles & Phillip E. Melton & Kevin Huynh & Natalie A. Mellett & Thy Duong & Anh Nguyen & Michelle Cinel & Alex Smith & Gavriel Olshansky & Tingting Wang & Marta Brozynska & Mike Ino, 2022. "Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Chamlee Cho & Beomsu Kim & Dan Say Kim & Mi Yeong Hwang & Injeong Shim & Minku Song & Yeong Chan Lee & Sang-Hyuk Jung & Sung Kweon Cho & Woong-Yang Park & Woojae Myung & Bong-Jo Kim & Ron Do & Hyon K., 2024. "Large-scale cross-ancestry genome-wide meta-analysis of serum urate," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    7. Md. Moksedul Momin & Jisu Shin & Soohyun Lee & Buu Truong & Beben Benyamin & S. Hong Lee, 2023. "A method for an unbiased estimate of cross-ancestry genetic correlation using individual-level data," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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