IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-11892-5.html
   My bibliography  Save this article

GSNOR provides plant tolerance to iron toxicity via preventing iron-dependent nitrosative and oxidative cytotoxicity

Author

Listed:
  • Baohai Li

    (Zhejiang University
    Salk Institute for Biological Studies
    Salk Institute for Biological Studies
    Vienna Biocenter (VBC))

  • Li Sun

    (Chinese Academy of Sciences)

  • Jianyan Huang

    (Salk Institute for Biological Studies
    Salk Institute for Biological Studies)

  • Christian Göschl

    (Vienna Biocenter (VBC))

  • Weiming Shi

    (Chinese Academy of Sciences)

  • Joanne Chory

    (Salk Institute for Biological Studies
    Salk Institute for Biological Studies)

  • Wolfgang Busch

    (Salk Institute for Biological Studies
    Salk Institute for Biological Studies
    Vienna Biocenter (VBC))

Abstract

Iron (Fe) is essential for life, but in excess can cause oxidative cytotoxicity through the generation of Fe-catalyzed reactive oxygen species. It is yet unknown which genes and mechanisms can provide Fe-toxicity tolerance. Here, we identify S-nitrosoglutathione-reductase (GSNOR) variants underlying a major quantitative locus for root tolerance to Fe-toxicity in Arabidopsis using genome-wide association studies and allelic complementation. These variants act largely through transcript level regulation. We further show that the elevated nitric oxide is essential for Fe-dependent redox toxicity. GSNOR maintains root meristem activity and prevents cell death via inhibiting Fe-dependent nitrosative and oxidative cytotoxicity. GSNOR is also required for root tolerance to Fe-toxicity throughout higher plants such as legumes and monocots, which exposes an opportunity to address crop production under high-Fe conditions using natural GSNOR variants. Overall, this study shows that genetic or chemical modulation of the nitric oxide pathway can broadly modify Fe-toxicity tolerance.

Suggested Citation

  • Baohai Li & Li Sun & Jianyan Huang & Christian Göschl & Weiming Shi & Joanne Chory & Wolfgang Busch, 2019. "GSNOR provides plant tolerance to iron toxicity via preventing iron-dependent nitrosative and oxidative cytotoxicity," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11892-5
    DOI: 10.1038/s41467-019-11892-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-11892-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-11892-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Matthieu Pierre Platre & Santosh B. Satbhai & Lukas Brent & Matias F. Gleason & Min Cao & Magali Grison & Marie Glavier & Ling Zhang & Christophe Gaillochet & Christian Goeschl & Marco Giovannetti & B, 2022. "The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11892-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.